Tip 2 diabetes mellituslu hastalarda plazma homosistein düzeyinin normal popülasyonla karşılaştırılması

Erşan, İsmail; Öztürk, Banu Turgut; Kamış, Ümit; Özkağnıcı, Ahmet; Gündüz, Kemal
June 2012
Journal of Clinical & Experimental Investigations / Klinik ve De;2012, Vol. 3 Issue 2, p235
Academic Journal
Objectives: To compare the plasma homocysteine levels between control group and diabetic patients with no diabetic retinopathy, with preproliferative diabetic retinopathy, with proliferative diabetic retinopathy. Materials and methods: Plasma homocysteine levels of 23 diabetic patients were measured and were compared with 25 age-matched controls with no systemic problem and no ocular disease. Plasma homocysteine levels were measured using high-performance liquid chromatography. Results: Diabetic patients were divided into three groups according to their ophthalmological findings. There were 8 patients with no diabetic retinopathy, 8 patients with preproliferative diabetic retinopathy, 7 patients with proliferative diabetic retinopathy. Plasma homocysteine levels were higher in diabetic patients (13.30±4.03 μmol/L) compared to the control group (11.71±3.41 μmol/L) but no statistically significant difference was found between the two groups (p>0.05). Plasma homocysteine levels were measured 12.50±3.73 μmol/L in no diabetic retinopathy group, 12.90±2.59 μmol/L in preproliferative diabetic retinopathy group, 14.64±5.69 μmol/L in proliferative diabetic retinopathy group. In diabetic group, plasma homocysteine levels increased with the increase of the severity of retinopathy but not reached statistically significance (p>0.05). Conclusion: Although no statistically significance was found, retinopathy progresses with the increase of plasma homocysteine levels. This can be used for the followup of the diabetic patients but further evaluation in large groups is needed.


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