TITLE

A Study on the Estrogen Receptor α Gene Polymorphism and Its Expression in Thin Endometrium of Unknown Etiology

AUTHOR(S)
Yuan, Rui; Le, Ai-Wen
PUB. DATE
July 2012
SOURCE
Gynecologic & Obstetric Investigation;Jul2012, Vol. 74 Issue 1, p13
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background/Aims: To study the relationship between the estrogen receptor α (ERa) gene polymorphism and expression in thin endometrium. Methods: We chose 120 unknown thin endometrium patients as the case group and another 112 normal endometrium women as the control group. Methods in molecular biology were used to analyze restriction fragment length polymorphism of PvuII and XbaI in the ERa gene. RT-PCR and Western blot were used to investigate the expressions of the ERa at mRNA and protein levels. Results: P genotypic frequency was 47.1% in the case group and 30.0% in the control group; the OR was 2.076. X genotypic frequency in the case group was 20.8%, and 30.4% in the control group; the OR was 0.602. Restriction fragment length polymorphism of PvuII and XbaI in the two groups were distributed with polymorphisms. The mRNA and protein expressions of ERa decreased compared with that in the control group (p < 0.05). Conclusions: ERa gene polymorphism is related to unknown thin endometrium, in which P allele may be the risk and X allele may be its guard factor. The expression of ERa decreases in thin endometrium compared with normal endometrium, and ERa may be related to the unknown etiological thin endometrium. Copyright © 2012 S. Karger AG, Basel
ACCESSION #
78164473

 

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