Structure of a heparin-linked biologically active dimer of fibroblast growth factor

DiGabriele, Anna D.; Lax, Irit; Chen, Denise I.; Scahn, Carl M.; Jaye, Michael; Schlessinger, Joseph; Hendrickson, Wayne A.
June 1998
Nature;6/25/1998, Vol. 393 Issue 6687, p812
Academic Journal
Describes the x-ray crystal structure of a biologically active dimer of human acidic fibroblast growth factor (FGF) in a complex with a fully sulphated, homogeneous heparin decassacharide. How FGFs regulate various biological responses; Heparins as linear anionic polysaccharide chains.


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