Persistent cavitations in pulmonary mucormycosis after apparently successful amphotericin B

Donado-Uña, José R.; Dıaz-Hellın, Vicente; López-Encuentra, Angel; Echave-Sustaeta, José M.
May 2002
European Journal of Cardio-Thoracic Surgery;May2002, Vol. 21 Issue 5, p940
Academic Journal
A 67-year-old diabetic male developed bilateral pulmonary mucormycosis (PM). After long-term treatment with amphotericin B (cumulative dose of 30.6 g), clinical resolution was obtained, but small radiographic cavitations persisted. A late relapse occurred and bilateral lobectomy led to a definitive cure. Amphotericin B is not able to penetrate properly into PM cavitations. We suggest that persistence of cavitations should lead to consideration of surgery, even after a good response to amphotericin B.


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