Synthesis of Mitoxantrone Analogues and their in-vitro Cytotoxicity

Kumar, P. Hareesh; Prakash, S. Shiva; Kumar, S. Krishna; Diwakar, Latha; Reddy, G. Chandrasekara
April 2011
International Journal of ChemTech Research;Apr-Jun2011, Vol. 3 Issue 2, p690
Academic Journal
Mitoxantrone (Mx) is a powerful neoplastic agent but its cardiotoxicity has become a concern. Since we developed an improved method for the preparation of 4, 5-diaminochrysazin which is a precursor for the synthesis of mitoxantrone, we attempted making several analogues having 3 carbon to 7 carbon atom side chains starting from beta alanino, cyclopropyl, cyclopentyl, cyclohexyl and benzyl groups. All these compounds showed a comparable cytotoxicity in-vitro when tested against MCF-7 breast cancer and Hela cervical cancer cell lines. Among these, 1, 4-bis (cyclohexylamino) 5, 8-dihydroxyanthraquinone-9, 10-dione appeared promising for further in-vivo studies.


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