TITLE

EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma

PUB. DATE
January 2012
SOURCE
Journal of Biomedical Science;2012, Vol. 19 Issue 1, p40
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article offers information on the research conducted by the authors related to the correlation between the epidermal growth factor receptor (EGFR) and chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma (CCRCC). It states that the study aimed at analyzing protein expression of EGFR by immunohistochemistry and to investigate the role of EGFR gene copy number changes in relation to EGFR overexpression in this type of renal cancer.
ACCESSION #
77688083

 

Related Articles

  • Myxoid Adrenocortical Neoplasms. Jing Zhang; Jian Sun; Zhiyong Liang; Jie Gao; Xuan Zeng; Tonghua Liu // American Journal of Clinical Pathology;Nov2011, Vol. 136 Issue 5, p783 

    The histopathologic features of 10 myxoid adrenocortical neoplasms were analyzed, and epidermal growth factor receptor (EGFR) expression, EGFR gene copy number, and EGFR gene mutations in the 10 tumors were detected by using immunohistochemical analysis, fluorescence in situ hybridization, and...

  • Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. Ettl, T; Baader, K; Stiegler, C; Müller, M; Agaimy, A; Zenk, J; Kühnel, T; Gosau, M; Zeitler, K; Schwarz, S; Brockhoff, G // British Journal of Cancer;2/14/2012, Vol. 106 Issue 4, p719 

    Background:Activity of the tumour-suppressor gene PTEN is reduced in different types of cancer and implicates non-responsiveness to targeted therapy. This study evaluates the gene and protein status of PTEN in salivary gland carcinomas.Methods:A total of 287 carcinomas of the major and minor...

  • Chromophobe renal cell carcinoma with prominent lymph node metastasis and polysomy of chromosome 21: poorly differentiated form or 'presarcomatoid' form? Kuroda, Naoto; Tamura, Masato; Hes, Ondrej; Michal, Michal; Shuin, Taro; Toi, Makoto; Hayashi, Yoshihiro; Lee, Gang-Hong // Medical Molecular Morphology;Sep2011, Vol. 44 Issue 3, p168 

    Lymph node metastasis of chromophobe renal cell carcinoma (RCC) is extremely rare. It has been recently reported that sarcomatoid chromophobe RCC frequently show polysomy of chromosomes 1, 2, 6, 10, and 17. In this article, we report an unusual case of chromophobe RCC. A 42-year-old Japanese...

  • Acquired cystic disease-associated renal cell carcinoma: an immunohistochemical and fluorescence in situ hybridization study. Kuroda, Naoto; Yamashita, Motoki; Kakehi, Yoshiyuki; Hes, Ondrej; Michal, Michal; Lee, Gang-Hong // Medical Molecular Morphology;Dec2011, Vol. 44 Issue 4, p228 

    Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has been recently identified. However, there are only a few genetic studies to date. In this article, we performed an immunohistochemical and fluorescence in situ hybridization (FISH) study for six cases including one case with...

  • Triple-Negatif/Bazal Benzeri Meme Kanserinin Ä°mmünohistokimyasal Özellikleri. PALA, Emel Ebru; BAYOL, Ümit; CUMURCU, Süheyla; KESKİN, Elif // Turkish Journal of Pathology;2012, Vol. 28 Issue 3, p238 

    Objective: Triple-negative-breast-cancer that accounts for 10-20% of all breast carcinomas is defined by the lack of estrogen receptor, progesterone receptor, HER2 expression, and agressive clinical behavior. Triple-negative-breast-cancer is categorized into basal like and other types. The...

  • Papillary glioneuronal tumor-a rare entity: report of four cases and brief review of literature. Agarwal, Shipra; Sharma, Mehar; Singh, Geetika; Suri, Vaishali; Sarkar, Chitra; Garg, Ajay; Kumar, Rajinder; Chandra, P. // Child's Nervous System;Nov2012, Vol. 28 Issue 11, p1897 

    Purpose: Papillary glioneuronal tumors (PGNT) have been recently included as a distinct entity in the WHO classification of tumors of the central nervous system. Their molecular pathogenesis is not clear. In the current study, we present the morphological, immunohistochemical, and molecular...

  • Adrenal cortical neoplasms: a study of clinicopathological features related to epidermal growth factor receptor gene status. Jing Zhang; Cuiping Wang; Jie Gao; Jian Sun; Xuan Zeng; Shafei Wu; Zhiyong Liang // Diagnostic Pathology;2014, Vol. 9 Issue 1, p1 

    Background Adrenocortical carcinoma (ACC) is a rare but highly malignant neoplasm with limited treatment options. Methods In this study, the clinicopathological features of 22 ACCs and 22 adrenocortical adenomas (ACA) were analyzed, and the EGFR protein expression, EGFR gene mutation status and...

  • Gene Amplification of Epidermal Growth Factor Receptor in Atypical Glottic Hyperplasia. Braut, Tamara; Kujundzić, Milodar; Vukelić, Jelena; Manestar, Dubravko; Krstulja, Mira // Collegium Antropologicum;Nov2012 Supplement 2, Vol. 36, p87 

    The study searched for epidermal growth factor receptor (EGFR) gene amplification in hyperplastic glottis lesions. After classical pathohistological findings of hematoxylin-eosin (HE) slides and quantitative immunohistochemical (IHC) analysis, fluorescent in situ hybridization (FISH) was used on...

  • Phase II study on lapatinib in advanced EGFR-positive chordoma†. Stacchiotti, S.; Tamborini, E.; Lo Vullo, S.; Bozzi, F.; Messina, A.; Morosi, C.; Casale, A.; Crippa, F.; Conca, E.; Negri, T.; Palassini, E.; Marrari, A.; Palmerini, E.; Mariani, L.; Gronchi, A.; Pilotti, S.; Casali, P.G. // Annals of Oncology;Jul2013, Vol. 24 Issue 7, p1931 

    Background To report on a prospective, investigator-driven, phase II study on lapatinib in epidermal growth factor receptor (EGFR)-positive advanced chordoma patients. Patients and methods From December 2009 to January 2012, 18 advanced progressing chordoma patients entered this study (median...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics