TITLE

Synthesis and Antibacterial Activity of Some Heterocyclic Chalcone Analogues Alone and in Combination with Antibiotics

AUTHOR(S)
Thanh-Dao Tran; Thi-Thao-Nhu Nguyen; Tuong-Ha Do; Thi-Ngoc-Phuong Huynh; Cat-Dong Tran; Khac-Minh Thai
PUB. DATE
June 2012
SOURCE
Molecules;Jun2012, Vol. 17 Issue 6, p6684
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A series of simple heterocyclic chalcone analogues have been synthesized by Claisen Schmidt condensation reactions between substituted benzaldehydes and heteroaryl methyl ketones and evaluated for their antibacterial activity. The structures of the synthesized chalcones were established by IR and ¹H-NMR analysis. The biological data shows that compounds p5, f6 and t5 had strong activities against both susceptible and resistant Staphylococcus aureus strains, but not activity against a vancomycin and methicillin resistant Staphylococcus aureus isolated from a human sample. The structure and activity relationships confirmed that compounds f5, f6 and t5 are potential candidates for future drug discovery and development.
ACCESSION #
77651526

 

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