TITLE

Blood Transfusions Correlate with Infections in Trauma Patients in a Dose-Dependent Manner

AUTHOR(S)
Claridge, Jeffrey A.; Sawyer, Robert G.; Schulman, Andrew M.; McLemore, Elizabeth C.; Young, Jeffrey S.
PUB. DATE
July 2002
SOURCE
American Surgeon;Jul2002, Vol. 68 Issue 7, p566
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Infections are a common and significant sequela of major traumatic injury. The objective of this study was to evaluate the relationship between infections in trauma patients and the transfusion of packed red blood cells (pRBCs) within the first 48 hours of admission. We hypothesized that transfusions of pRBCs were associated with an increased risk of infection in a dose-dependent manner. All adult patients admitted to the trauma service of a Level I trauma center from November 1996 to December 1999 were studied. Secondary analysis was performed on prospectively collected data. One thousand five hundred ninety-three consecutive patients were studied; of these 12.6 per cent developed at least one infection. The overall transfusion rate was 19.4 per cent. The infection rate in patients who received at least one transfusion was significantly higher (P < 0.0001) at 33.0 versus 7.6 per cent in patients receiving no pRBCs. Transfusions per patient ranged from 0 to 46 units. There was a clear exponential correlation in patients receiving between 0 and 15 transfusions (R² = 0.757). Multivariate logistic regression, which was used to identify risk factors for the development of infection, demonstrated the odds ratio of receiving pRBCs to be 1.084, with a 95 per cent confidence interval of 1.028 to 1.142 (P = 0.0028). In summary there is a clear dose-dependent correlation between transfusions of pRBCs and the development of infection in trauma patients. Multivariate analysis further demonstrated that pRBCs were an independent risk factor for the development of infections. Although transfusions are frequently indicated, they should be administered appropriately and with no more pRBCs than absolutely necessary.
ACCESSION #
7752189

 

Related Articles

  • Wound complication of minimally invasive plate osteosynthesis in distal tibia fractures. T. Lau; F. Leung; C. Chan; S. Chow // International Orthopaedics;Oct2008, Vol. 32 Issue 5, p697 

    Abstract  Nowadays, the use of minimally invasive plate osteosynthesis (MIPO) in the management of fracture of the distal tibia is common. The various advantages of the MIPO technique, namely, preserving blood supply and better bone healing, have been described extensively in the...

  • Bleeding Manifestations After Early Use of Low-Molecular-Weight Heparins in Blunt Splenic Injuries. Alejandro, Kathia V.; Acosta, José A.; Rodríguez, Pablo A. // American Surgeon;Nov2003, Vol. 69 Issue 11, p1006 

    Low-molecular-weight heparins (LMWHs) have emerged as an effective method for deep venous thrombosis (DVT) prophylaxis after major trauma. The early use of LMWH in patients with splenic injuries may result in increased rates of blood transfusions and failure of nonoperative management. A...

  • Postoperative blood transfusion is an independent predictor of acute kidney injury in cardiac surgery patients. Freeland, Kristofer; Jahromi, Alireza Hamidian; Duvall, Lucas Maier; Mancini, Mary Catherine // Journal of Nephropathology;Oct2015, Vol. 4 Issue 4, p121 

    Background: Acute kidney injury (AKI) is a serious complication of cardiac surgery with cardiopulmonary bypass (CPB) which increases postoperative morbidity and mortality. Objectives: The study was designed to assess the incidence of AKI and associated risk factors in patients undergoing CPB...

  • Isolated blunt splenic injury: Do we transfuse more in an attempt to operate less? Balaa, Fady; Yelle, Jean-Denis; Pagliarello, Giuseppe; Lorimer, John; O'Brien, Jo-Anne // Canadian Journal of Surgery;Dec2004, Vol. 47 Issue 6, p446 

    Objective: To determine if blood transfusion requirements in patients with isolated blunt splenic injury (BSI) are greater if they arc managed nonoperatively, we did a retrospective case study of patients with isolated BSI who were seen at a Canadian university teaching hospital over a 10-year...

  • Consenting Operative Orthopaedic Trauma Patients: Challenges and Solutions. Kheiran, Amin; Banerjee, Purnajyoti; Stott, Philip // ISRN Otolaryngology;2014, p1 

    Guidelines exist to obtain informed consent before any operative procedure. We completed an audit cycle starting with retrospective review of 50 orthopaedic trauma procedures (Phase 1 over three months to determine the quality of consenting documentation). The results were conveyed and adequate...

  • Blood bank.  // MLO: Medical Laboratory Observer;Nov2002, Vol. 34 Issue 11, p9 

    Reports on transmission-related acute lung injury (TRALI) in blood transfusion patients in the U.S. Risk factors causing the problem; Role of screening high risk donors exposed to multiple blood groups in preventing the problem; Need for further research into TRALI.

  • Transfusionsassoziierte akute Lungeninsuffizienz. Tank, S.; Sputtek, A.; Kiefmann, R. // Anaesthesist;Apr2013, Vol. 62 Issue 4, p254 

    Transfusion-related acute lung injury (TRALI) developed into the leading cause of transfusion-related morbidity and mortality after the first description by Popovsky et al. approximately three decades ago. It was the most frequent reason for transfusion-related fatalities worldwide before...

  • Blood transfusion and cytokines' changes in total knee replacement. Drosos, Georgios; Blatsoukas, Konstantinos; Ververidis, Athanasios; Tripsianis, Grigorios; Chloropoulou, Pelagia; Iatrou, Christos; Kazakos, Konstantinos; Verettas, Dionisios-Alexandros // Archives of Orthopaedic & Trauma Surgery;Oct2012, Vol. 132 Issue 10, p1505 

    Introduction: The aim of this prospective comparative study was to evaluate the serum levels of different cytokines and the frequency of adverse reactions and wound infections in patients who underwent total knee replacement (TKR) and were not transfused or received either allogeneic blood...

  • special ingredient: arnica. Rossi, Carey // Better Nutrition;May2006, Vol. 68 Issue 5, p40 

    This article presents information on the usefulness of the mountain flower arnica in the treatment of wounds and injuries. This bright daisy like flower, may be just the thing to alleviate one's ailments. Used topically, arnica may help relieve mild pain, kill bacteria, fight inflammation and...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics