TITLE

Effect of Vaccines and Antivirals during the Major 2009 A(H1N1) Pandemic Wave in Norway - And the Influence of Vaccination Timing

AUTHOR(S)
de Blasio, Birgitte Freiesleben; Iversen, Bj�rn G.; Tomba, Gianpaolo Scalia
PUB. DATE
January 2012
SOURCE
PLoS ONE;Jan2012, Vol. 7 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To evaluate the impact of mass vaccination with adjuvanted vaccines (eventually 40% population coverage) and antivirals during the 2009 influenza pandemic in Norway, we fitted an age-structured SEIR model using data on vaccinations and sales of antivirals in 2009/10 in Norway to Norwegian ILI surveillance data from 5 October 2009 to 4 January 2010. We estimate a clinical attack rate of approximately 30% (28.7-29.8%), with highest disease rates among children 0-14 years (43-44%). Vaccination started in week 43 and came too late to have a strong influence on the pandemic in Norway. Our results indicate that the countermeasures prevented approximately 11-12% of potential cases relative to an unmitigated pandemic. Vaccination was found responsible for roughly 3 in 4 of the avoided infections. An estimated 50% reduction in the clinical attack rate would have resulted from vaccination alone, had the campaign started 6 weeks earlier. Had vaccination been prioritized for children first, the intervention should have commenced approximately 5 weeks earlier in order to achieve the same 50% reduction. In comparison, we estimate that a non-adjuvanted vaccination program should have started 8 weeks earlier to lower the clinical attack rate by 50%. In conclusion, vaccination timing was a critical factor in relation to the spread of the 2009 A(H1N1) influenza. Our results also corroborate the central role of children for the transmission of A(H1N1) pandemic influenza.
ACCESSION #
77507344

 

Related Articles

  • Effect of Vaccines and Antivirals during the Major 2009 A(H1N1) Pandemic Wave in Norway - And the Influence of Vaccination Timing. de Blasio, Birgitte Freiesleben; Iversen, Bjørn G.; Tomba, Gianpaolo Scalia // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    To evaluate the impact of mass vaccination with adjuvanted vaccines (eventually 40% population coverage) and antivirals during the 2009 influenza pandemic in Norway, we fitted an age-structured SEIR model using data on vaccinations and sales of antivirals in 2009/10 in Norway to Norwegian ILI...

  • PANDEMIA DE GRIPÄ‚ H1N1 -- 2009.  // Romanian Journal of Infectious Diseases;2010, Vol. 13 Issue 3, p156 

    No abstract available.

  • Influenza pandemics: past, present and future challenges. Flahault, Antoine; Zylberman, Patrick // Public Health Reviews (2107-6952);2010, Vol. 32 Issue 1, p319 

    Influenza epidemics occur regularly and prediction of their conversion to pandemics and their impact is diffi cult. Coordination of efforts on a global scale to control or reduce the impact is fraught with potential for under and overreaction. In light of the 1956 pandemic and more recently the...

  • The changing phases of pandemic (H1N1) 2009 in Queensland: an overview of public health actions and epidemiology. Appuhamy, Ranil D; Beard, Frank H; Phung, Hal N; Selvey, Christine E; Birrell, Frances A; Culleton, Terry H // Medical Journal of Australia;1/18/2010, Vol. 192 Issue 2, p94 

    The article discusses the responses of Queensland to the H1N1 pandemic during the early stages up to June 22, 2009 when the country went into the "Protect" phase. The Delay phase lasted from April 28, 2009 to May 21, 2009 and focused on early identification and management. During the Contain...

  • Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection. Zarychanski, Ryan; Stuart, Tammy L.; Kumar, Anand; Doucette, Steve; Elliott, Lawrence; Kettner, Joel; Plummer, Frank // CMAJ: Canadian Medical Association Journal;2/23/2010, Vol. 182 Issue 3, p257 

    Background: In the context of 2009 pandemic influenza (H1N1) virus infection (pandemic H1N1 influenza), identifying correlates of the severity of disease is critical to guiding the implementation of antiviral strategies, prioritization of vaccination efforts and planning of health...

  • Flu season's almost here: Are you ready? Campos-Outcalt, Doug // Journal of Family Practice;Sep2010, Vol. 59 Issue 9, p514 

    The article offers recommendations for family physicians regarding the prevention of influenza in patients. It mentions about the H1N1 influenza pandemic that took place in 2009 and stresses on the importance of immunization for preventing influenza pandemic. Also suggested are dosage of...

  • Influenza A Pandemic (P- H1N1) Flu and its Circulation Trend in Northern India: A Review. Tiwari, Nivedita; Verma, Sheetal; Dhole, T. N. // International Journal of Pharmaceutical Sciences Review & Resear;Mar/Apr2014, Vol. 25 Issue 2, p252 

    The respiratory viral infections remain a major cause of morbidity and mortality in both children and adults. The notable among these is influenza virus which is responsible for large scale annual epidemics. The H1N1 pandemic strain which is in circulation since 2009 seems to be a reassortment...

  • Withholding flu drugs from seniors a new discussion item.  // Long-Term Living: For the Continuing Care Professional;Sep2009, Vol. 58 Issue 9, p10 

    The article reports on the suggestion of researchers from Italy's Bruno Kessler Foundation that the elderly should be the last in line to receive swine flu drugs. According to the researchers, giving antiviral drugs to older people would not decrease mortality and may even increase resistance....

  • Swine flu: lessons we need to learn from our global experience. Collignon, Peter // Emerging Health Threats;2011, Vol. 4, p1 

    There are important lessons to be learnt from the recent 'Swine Flu' pandemic. Before we call it a pandemic, we need to have appropriate trigger points that involve not only the spread of the virus but also its level of virulence. This was not done for H1N1 (swine flu). We need to ensure that we...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics