Fibrin Sealant Facilitates Hemostasis in Arteriovenous Polytetrafluoroethylene Grafts for Renal Dialysis Access

Schenk III, Worthington G.; Goldthwaite Jr., Charles A.; Burks, Sandra; Spotnitz, William D.
August 2002
American Surgeon;Aug2002, Vol. 68 Issue 8, p728
Academic Journal
A prospective randomized study was performed to evaluate the efficacy of fibrin sealant(FS) in patients undergoing upper-extremity polytetrafluoroethylene (PTFE) graft placement for dialysis. This procedure appears to be a reproducible and clinically relevant model for evaluating FS in vascular surgery. Consenting adult patients (n = 28) undergoing placement of a PTFE graft (6 mm) were randomized to either the treatment group using FS (Hemaseel APR, Haemacure Corp., Sarasota, FL) or control comparator groups (four) of bovine thrombin (T) (Thrombogen, GenTrac Inc., Middleton, WI), pressure (P), bovine thrombin (Thrombogen, GenTrac Inc.) - soaked cellulose sponges (TG) (Gelfoam, Upjohn Co., Kalamazoo, MI), or oxidized regenerated cellulose (S) (Surgicel, Johnson & Johnson, New Brunswick, NJ). All patients received heparin (3000 IU intravenous push) before placement of vascular clamps. The mean time to hemostasis was 29.3 seconds for FS, 147.4 seconds for T, 872.2 seconds for P, 346 seconds for TG, and 1044.5 seconds for S. There were no significant adverse events. FS appeared to be a superior hemostatic agent in these vascular procedures. No complications from FS were noted.


Related Articles

  • Upper Arm Polytetrafluoroethylene Grafts for Dialysis Access. Analysis of Two Different Graft Sized: 6 mm and 6-8 mm. García-Pajares, Rosario; Polo, José R.; Flores, Ángel; Gonzalez-Tabares, Enrique; Solís, Juan V. // Vascular & Endovascular Surgery;Sep/Oct2003, Vol. 37 Issue 5, p335 

    The purpose of this retrospective study was to analyze 2 sizes of expanded polytetrafluoroethyIene (PTFE) upper arm grafts for dialysis: 8 millimeters, tapered to 6 mm at the arterial side, and 6 millimeters. All upper arm PTFE grafts (Gore-Tex®) were performed between January 1981 and April...

  • Even Short Periods on Dialysis Significantly Increase Mortality Post-Transplant.  // Kidney;Nov/Dec98, Vol. 7 Issue 6, p269 

    Presents an abstract of the study 'Even Short Periods on Dialysis Significantly Increase Mortality Post-Transplant,' by F.G. Cosio.

  • The Influence of Barrier Membranes on Autologous Bone Grafts. Gielkens, P. F. M.; Schortinghuis, J.; De Jong, J. R.; Paans, A. M. J.; Ruben, J. L.; Raghoebar, G. M.; Stegenga, B.; Bos, R. R. M. // Journal of Dental Research;Nov2008, Vol. 87 Issue 11, p1048 

    In implant dentistry, there is continuing debate regarding whether a barrier membrane should be applied to cover autologous bone grafts in jaw augmentation. A membrane would prevent graft remodeling with resorption and enhance graft incorporation. We hypothesized that membrane coverage does not...

  • Renal transplantation--1972. Lazarus, J. M.; Hampers, C. L. // Annals of Internal Medicine;Mar72, Vol. 76 Issue 3, p504 

    Comments on the survival rate related to renal transplantation in 1972. Laboratory tests for renal surgical preparations; Factors that affected renal transplantation; Involvement of patients with dialysis-transplant programs.

  • Renal transplantation, chronic dialysis, and chronic renal insufficiency in children and adolescents. The 1995 Annual Report of the North American Pediatric Renal Transplant Cooperative Study. Warady, Bradley A.; Hébert, Diane; Sullivan, E. Kenneth; Alexander, Steven R.; Tejani, Amir // Pediatric Nephrology;1997, Vol. 11 Issue 1, p49 

    The 1995 Annual Report of the North American Pediatric Renal Transplant Cooperative Study summarizes data voluntarily collected from 123 centers on 5,197 children and adolescents grouped into three cohorts: (1) patients who received renal transplants on or after 1 January 1987 (n = 3,066), (2)...

  • Kidney transplantation in young children: should there be a minimum age? Humar, A.; Arrazola, L.; Mauer, M.; Matas, A. J.; Najarian, J. S. // Pediatric Nephrology;Dec2001, Vol. 16 Issue 12, p941 

    The optimal age for transplantation in children with end-stage renal disease remains controversial. Many centers have adopted a policy of waiting until such children reach a certain minimum age or weight, maintaining them on chronic dialysis until then. Their policy is based on historical data...

  • Abstracts.  // Kidney International;Jun1976, Vol. 9 Issue 6, p520 

    Presents abstracts of articles published in the 1976 issue of "Kidney International." "Increased Calcitonin Plasma Concentrations in Chronic and Early Acute Renal Failure," by R. Ardaillou, R. Isaac and M. Beaufils; "Serial Histomorphometric and Histochemical Bone Biopsy Studies in Dialysis and...

  • Graft surveillance: Venous pressure, access flow, or the combination? Smits, Johannes H.M.; Van Der Linden, Joke; Hagen, E. Chris; Modderkolk-Cammeraat, Esther C.; Feith, Geert W.; Koomans, Hein A.; Van Den Dorpel, Marinus A.; Blankestijn, Peter J. // Kidney International;Apr2001, Vol. 59 Issue 4, p1551 

    Graft surveillance: Venous pressure, access flow, or the combination? Background. Increased venous pressure (VP) and decreased access flow (Qa) are predictors of dialysis access graft thrombosis. VP is easily obtainable. Qa assessment requires a special device and takes more time. The aims of...

  • Kidney Transplant Recipient Referral and Evaluation. Bell, Jenny; Ross, Kristi // Nephrology Nursing Journal;Oct2002, Vol. 29 Issue 5, p477 

    Focuses on the referral and evaluation process of kidney transplantation recipients. Benefits of kidney transplantation prior to dialysis; Contraindications in transplant centers; Information on the generally accepted relative contraindications to a transplant; Requirements for pre-natal...

  • Infections in dialysis and transplant patients in tropical countries. Jha, Vivekanand; Chugh, Sumant; Chugh, Kirpal S. // Kidney International Supplement;Jan2000, Issue 74, pS-85 

    Focuses on infections in dialysis and transplant patients in tropical countries. Factors contributing to the infections complicating the course of transplant patients; Problems in the treatment of post-transplant tuberculosis; Role of isoniazid prophylaxis after transplant.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics