TITLE

Prognostic Factors Associated with Resectable Carcinoma of the Esophagus

AUTHOR(S)
Christein, John D.; Hollinger, Edward F.; Millikan, Keith W.
PUB. DATE
March 2002
SOURCE
American Surgeon;Mar2002, Vol. 68 Issue 3, p258
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A retrospective review of esophagectomy for esophageal carcinoma between 1982 and 1999 was performed. Two hundred twenty-two patients (mean age 61.7 years) underwent esophagectomy: 128 transhiatal, 74 Ivor Lewis, and 20 abdominal. Most tumors were adenocarcinoma (65%); the majority were in the lower third or cardia (78%). Excluding operative mortality the one-, 3-, and 5-year survival rates were 67, 39, and 31 per cent (median survival, 16.3 months) respectively. The hospital mortality rate was 6.8 per cent. Through univariate analysis race other than white, history of weight loss, poor or moderate differentiation (P = 0.05), full-thickness invasion (P = 0.02), positive lymph nodes (P < 0.01), Ivor Lewis esophagectomy (P = 0.02), intraoperative blood transfusion (P = 0. 01), and tumor location in the upper or middle third in node-positive patients (P = 0.02) were associated with a poorer survival. Adjuvant therapy improved survival for patients with positive lymph nodes (P < 0.01). In multivariate analysis positive lymph nodes, tumor location, intraoperative blood transfusion, and adjuvant therapy were independent predictors of survival. To optimize survival esophagectomy for esophageal carcinoma should be performed without blood transfusion, and node-positive patients should receive multimodal therapy.
ACCESSION #
7742035

 

Related Articles

  • Can extent of high grade dysplasia in Barrett's oesophagus predict the presence of adenocarcinoma at oesophagectomy? Dar, M.S.; Goldblum, J.R.; Rice, T.W.; Falk, G.W. // Gut;Apr2003, Vol. 52 Issue 4, p486 

    Background: Optimal management of Barrett's oesophagus complicated by high grade dysplasia is controversial. Recently, the extent of high grade dysplasia was described as a predictor of subsequent development of cancer in patients undergoing continued surveillance. However, there is no universal...

  • Primary malignant melanoma of the esophagus. de Perrot; Br√ľndler; Robert; Spiliopoulos // Diseases of the Esophagus;Jun2000, Vol. 13 Issue 2, p172 

    A case of primary malignant melanoma of the esophagus is reported, followed by a review of the literature. The clinical presentation of this uncommon tumor is similar to esophageal carcinoma and the preoperative diagnosis may be difficult. A total esophagectomy is the treatment of choice. The...

  • Prospective evaluation of preoperative chemotherapy in resectable squamous cell carcinoma of the thoracic esophagus. Baba; Natsugoe; Shimada; Nakano; Kusano; Fukumoto; Aikou; Akazawa // Diseases of the Esophagus;Jun2000, Vol. 13 Issue 2, p136 

    A prospective study was performed to clarify the surgical outcome of patients with esophageal carcinoma who would benefit from induction chemotherapy followed by surgery. Of 55 eligible patients, 42 (76.3%) agreed to randomization with either chemotherapy followed by surgery (n = 21) or surgery...

  • Risk factor analysis of post-operative mortality in oesophagectomy. Liu; Watson; Devitt; Mathew; Myburgh; Jamieson // Diseases of the Esophagus;Jun2000, Vol. 13 Issue 2, p130 

    Oesophagectomy for cancer is associated with a significant incidence of post-operative complications and death, and so this study sought to determine objective criteria which could better predict operative risk. Clinical risk factors for oesophagectomy and the results of objective investigations...

  • PS02.006: OPERATIVE INDICATION AND PROCEDURES OF THORACOSCOPIC ESOPHAGECTOMY FOR ESOPHAGEAL CANCER. Kamei, Takashi // Diseases of the Esophagus;Sep2018, Vol. 31 Issue 13, p121 

    Background Thoracoscopic esophagectomy has been performed for two decades and becomes widely spread. We evaluate our cases who undergone the thoracoscopic esophagectomy and consider the future prospective of this operation. Methods 702 patients who received thoracoscopic esophagectomy in our...

  • RESULTS OF IVOR LEWIS ESOPHAGECTOMY FOR MID AND DISTAL ESOPHAGEAL CANCER: A SINGLE CENTER EXPERIENCE.  // European Surgical Research;Jul2006 Supplement 1, Vol. 38, p74 

    An abstract of the study "Results Of Ivor Lewis Esophagectomy For Mid And Distal Esophageal Cancer: A Single Center Experience," by W. Ceelen and colleagues and published in an issue of the "European Surgical Research" is presented.

  • Post-oesophagectomy and gastric pull-up: Anaesthetic implications. Raghunandan, M.; Biddappa, Chenanda A. // Indian Journal of Anaesthesia;Jan/Feb2013, Vol. 57 Issue 1, p98 

    A letter to the editor is presented in response to the article "Post-oesophagectomy and gastric pull-up: Anaesthetic implications" in the January-February 2013 issue.

  • Quality of life after oesophagectomy: the patients' perspective. Kirby; Kirby // Diseases of the Esophagus;Nov99, Vol. 12 Issue 3, p168 

    Narrates the experience of the author after esophagectomy for esophageal cancer in Great Britain. Inconvenience in the recovery from esophagectomy; Involvement of patients and carers in the treatment plan; Effects of surgical expertise on the quality of life.

  • Primary malignant melanoma of the esophagus treated by esophagectomy and systemic chemotherapy. Matsutani, T.; Onda, M.; Miyashita, M.; Hagiwara, N.; Akiya, Y.; Takubo, K.; Yamashita, K.; Sasajima, K. // Diseases of the Esophagus;Sep-Dec2001, Vol. 14 Issue 3/4, p241 

    We describe herein a case of asymptomatic primary malignant melanoma of the esophagus. A 65-year-old man presented with a 4-cm filling defect in the middle third of the esophagus on a routine barium swallow. Subtotal esophagectomy accompanied by lymph node dissection was performed through a...

  • VS01.01: STEP BY STEP INSTRUCTIONAL VIDEO OF MINIMALLY INVASIVE ESOPHAGECTOMY FOR ESOPHAGEAL CANCER FOR SURGEONS-IN-TRAINING IN A SINGAPORE INSTITUTION. Oo, Aung Myint // Diseases of the Esophagus;Sep2018, Vol. 31 Issue 13, p44 

    Description Tan Tock Seng Hospital is second largest hospital in Singapore. It is affiliated to two medical schools in Singapore and it is a training hospital for both undergraduate and postgraduate training. Minimally Invasive Esophagectomy for esophageal cancer is more and more popular...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics