Bastu, Ercan; Baysal, Bulent
April 2012
Acta Endocrinologica (1841-0987);Apr-Jun2012, Vol. 8 Issue 2, p249
Academic Journal
Context. Comparison of GnRH analogues and their impact on IVF treatment to improve pregnancy outcome. Objective. To compare the effects of GnRH agonists and GnRH antagonists on pregnancy rates. Design. A total of 458 women who had embryo transfers completed were analyzed retrospectively in a university hospital setting. Methods. Comparative data were gathered on pregnancy rates, FSH dosage, and number of follicles, retrieved oocytes and embryos. Results. The use of GnRH agonist showed a strong association with the number of follicles (GnRH antagonist: 11.45; GnRH agonist: 15.17), oocytes retrieved (GnRH antagonist: 10.66; GnRH agonist: 13.68) and embryos transferred (GnRH antagonist: 2.54; GnRH agonist: 2.89) (p<0.01). The use of GnRH antagonist showed a significant association with β- hCG > 5 mIU/mL pregnancy (GnRH antagonist 30.8%; GnRH agonist: 21.8%) (p<0.05). Ongoing pregnancy rates between the two GnRH analogues showed no statistically significant differences (GnRH antagonist 72.1%; GnRH agonist: 64.1%) (p>0.05). Conclusion. On the basis of current evidence, it is still unclear which GnRH analogue is the first choice for achieving a higher rate of pregnancy.


Related Articles

  • Clinical relevance for the fact that GnRH antagonists do not down-regulate the GnRH receptor. Gordon, Keith; Stegmann, Barbara J. // Human Reproduction;Apr2013, Vol. 28 Issue 4, p1144 

    No abstract available.

  • Better Results from GnRH Agonist vs. GnRH Antagonist Cycles.  // Fertility Weekly;1/29/2007, p5 

    The article cites a research conducted by Robert Medved and colleagues to compare the results of frozen-thawed blastocysts resulting from cycles using controlled ovarian stimulation with GnRH agonists versus GnRH antagonists. The researchers concluded that frozen-thawed blastocysts obtained from...

  • Involvement of nociceptin/orphanin FQ in release of hypothalamic GnRH mediated by ORL1 receptor in ovariectomized rats. Xiao-fei An; Hai-ping Chen; Shu-Ian Ma; Yi Feng; Jun-wei Had; Bo-ying Chen // Acta Pharmacologica Sinica;Sep2005, Vol. 26 Issue 9, p1039 

    To investigate effect of the nociceptin/orphanin FQ (OFQ) on hypothalamus gonadotropin-releasing hormone (GnRH) release in ovariectomized (OVX) rats. GnRH radioimmunoassay (RIA) was used to study the effect of OFQ on GnRH release in hypothalamus slices in vitro. Push-pull perfusion and...

  • LH Supplementation Improves Outcome of GnRH Antagonist Donor Cycles.  // Fertility Weekly;8/2/2004, p3 

    This article discusses use of luteinizing hormone (LH) in improving outcome of luteinizing hormone releasing hormone (GnRH) antagonist donor cycles. According to Spanish researcher B. Acevedo and colleagues, when embryo donors are given LH in addition to GnRH antagonists, the fertilization rates...

  • Cessation of gonadotropin-releasing hormone antagonist on triggering day in flexible multiple-dose protocol: A randomized controlled study. Hye Jin Chang; Jung Ryeol Lee; Byung Chul Jee; Chang Suk Suh; Won Don Lee; Seok Hyun Kim // Clinical & Experimental Reproductive Medicine;Jun2013, Vol. 40 Issue 2, p83 

    Objective: To investigate outcomes of stimulated IVF cycles in which GnRH antagonist was omitted on the ovulation triggering day. Methods: A total of 86 women who underwent controlled ovarian hyperstimulation with recombinant FSH and GnRH antagonist flexible multipledose protocols were recruited...

  • Use of GnRH antagonists in ovarian stimulation for assisted reproductive technologies compared to the long protocol. Meta-analysis. Ludwig, M.; Katalinic, A.; Diedrich, K. // Archives of Gynecology & Obstetrics;Nov2001, Vol. 265 Issue 4, p175 

    The use of GnRH antagonists has revolutionized ovarian stimulation for assisted reproduction. Two GnRH antagonists are clinically available, namely, cetrorelix and ganirelix. Several studies have directly compared these new stimulation protocols against the long GnRH agonist protocol. To...

  • Achievement of pregnancy three times in the same patient during luteal GnRH agonist administration. Papanikolaou, Evangelos G.; Platteau, Peter; Albano, Carola; Kolibianakis, Efstratios; Devroey, Paul // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Mar2005, Vol. 10 Issue 3, p347 

    Gonadotrophin-releasing hormone agonist (GnRHa) administration from the mid-luteal phase onwards is considered the gold standard of ovarian stimulation for IVF treatment. It might, however, coincide with an implanting spontaneous pregnancy. Concerns have therefore been raised with regard to the...

  • gonadorelin.  // Royal Society of Medicine: Medicines;2002, p272 

    This article presents information on gonadorelin, the hypothalamic hormone that acts on the pituitary gland to release the gonadotrophin hormones. It is therefore also known as luteinising hormone-releasing hormone. Gonadorelin is in fact the synthetic version of naturally occurring...

  • sermorelin.  // Royal Society of Medicine: Medicines;2002, p492 

    This article presents information on sermorelin which is an analogue of growth hormone-releasing hormone. It is used therapeutically in a newly introduced test primarily to assess secretion of growth hormone. It is administered through injection.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics