TITLE

THE EFFECT OF GnRH AGONIST VERSUS GnRH ANTAGONIST ON PREGNANCY RATE

AUTHOR(S)
Bastu, Ercan; Baysal, Bulent
PUB. DATE
April 2012
SOURCE
Acta Endocrinologica (1841-0987);Apr-Jun2012, Vol. 8 Issue 2, p249
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Context. Comparison of GnRH analogues and their impact on IVF treatment to improve pregnancy outcome. Objective. To compare the effects of GnRH agonists and GnRH antagonists on pregnancy rates. Design. A total of 458 women who had embryo transfers completed were analyzed retrospectively in a university hospital setting. Methods. Comparative data were gathered on pregnancy rates, FSH dosage, and number of follicles, retrieved oocytes and embryos. Results. The use of GnRH agonist showed a strong association with the number of follicles (GnRH antagonist: 11.45; GnRH agonist: 15.17), oocytes retrieved (GnRH antagonist: 10.66; GnRH agonist: 13.68) and embryos transferred (GnRH antagonist: 2.54; GnRH agonist: 2.89) (p<0.01). The use of GnRH antagonist showed a significant association with β- hCG > 5 mIU/mL pregnancy (GnRH antagonist 30.8%; GnRH agonist: 21.8%) (p<0.05). Ongoing pregnancy rates between the two GnRH analogues showed no statistically significant differences (GnRH antagonist 72.1%; GnRH agonist: 64.1%) (p>0.05). Conclusion. On the basis of current evidence, it is still unclear which GnRH analogue is the first choice for achieving a higher rate of pregnancy.
ACCESSION #
77415697

 

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