TITLE

EFFECTS OF LEPTIN ON METABOLIC BONE TURNOVER IN OVARIECTOMY RATS

AUTHOR(S)
Abdel-Sater, K. A.; Mansour, H.
PUB. DATE
April 2012
SOURCE
Acta Endocrinologica (1841-0987);Apr-Jun2012, Vol. 8 Issue 2, p189
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction. Under physiological conditions, maintenance of skeletal mass is the result of a tightly coupled process of bone formation and bone resorption. Disease states, osteoporosis included, arise when this delicate balance is disrupted such as in menopause. The aim of the present work was to study the effect of leptin supplementation on bone metabolism in ovariectomized adult female rats, by measuring indices of bone biomarkers. Material and methods. Forty adult female albino rats were chosen as an animal model for this study and divided into the four equal groups (n=10/group): Group I (control SHAM-operated group), Group II (ovariectomy group). Group III (alendronate group): Ovariectomized rats that received alendronate 0.1 mg/kg body weight i.p. daily for eight weeks. Group IV (leptin group): Ovariectomized rats that received leptin (10µg/kg body weight) i.p. daily for eight weeks. The obtained serum is required for determination of: Serum osteocalcin, alkaline phosphatase, calcium and phosphorus levels. Results. The obtained data revealed that: Treatment with alendronate or leptin caused significant decrease of serum osteocalcin, specific bone alkaline phosphatase and urinary deoxypyridinoline levels compared to ovariectomy group. Conclusions. The results obtained in the present study provide evidence that daily administration of leptin contributes significantly to improve the bone biomarkers of ovariectomy in rats. Leptin prevents ovariectomy induced increases in bone turnover in rats.
ACCESSION #
77415690

 

Related Articles

  • Lycopene Effects on Serum Mineral Elements and Bone Strength in Rats. Haidong Liang; Fang Yu; Zhihong Tong; Weifeng Zeng // Molecules;Jun2012, Vol. 17 Issue 6, p7093 

    This study investigated the beneficial effect of lycopene on bone biomarkers in ovariectomized (OVX) rats. Female Wistar rats were either sham operated or surgically ovariectomized and then fed with lycopene for 8 weeks. Serum Ca, P, alkaline phosphatase (ALP), interleukin 6 (IL-6) and bone gla...

  • Effects of Intranasal Salmon Calcitonin in Juvenile Idiopathic Arthritis: An Observational Study. Siamopoulou, A.; Challa, A.; Kapoglou, P.; Cholevas, V.; Mavridis, A.K.; Lapatsanis, P.D. // Calcified Tissue International;Jul2001, Vol. 69 Issue 1, p25 

    The aim of this study was to follow the changes in bone mineral density (BMD) and biochemical markers of bone turnover in 10 children (7.5-17.5 years of age) with severe juvenile idiopathic arthritis (JIA), during a 3-year therapy with salmon calcitonin (100 IU/day 2 months on and 2 off for a...

  • The Effects of Two Nigerian Made Perfumes on the Liver of Adult Wistar Rat. Akunna, G. G.; Saalu, L. C.; Ogunmodede, O. S.; Ogunlade, B.; Adefolaju, G. A.; Bello, A. J. // Journal of Medical Sciences;2011, Vol. 11 Issue 5, p220 

    The use of perfumes is becoming increasingly popular in our environment. Attention is therefore understandably being focused on the safety of these perfumes. Hence, this study aimed to determine changes in the anatomical parameters of the liver and the activities of the biomarker enzymes of the...

  • EFFECT OF ADMINISTRATION OF AQUEOUS EXTRACT OF HIPPOBROMUS PAUCIFLORUS LEAVES IN MALE WISTAR RATS. Pendota, S. C.; Yakubu, M. T.; Grierson, D. S.; Afolayan, A. J. // African Journal of Traditional, Complementary & Alternative Medi;Jan2010, Vol. 7 Issue 1, p40 

    The effect of administration of aqueous extract of Hippobromus pauciflorus (L.f.) Radlk (Sapindaceae) leaves at 50, 100 and 200 mg/kg body weight for 14 days on some biochemical parameters in male Wistar rats was investigated. The extract at all the doses tested did not significantly (P>0.05)...

  • Effect of Coconut (Cocos nucifera) Water on Some Serum Liver Enzyme Markers and Kidney Parameters in Paracetamol-Induced Rats. Nwodo, O. F. C.; Elijah, Parker; Ozoemena, N. // Journal of Pharmacy Research;Feb2010, Vol. 3 Issue 2, p301 

    Paracetamol which is a common drug used in the treatment of aches and pains is very toxic when taken in a single dose of 150mg/kg in adults and 200mg/kg in children. Coconut water, a natural isotonic beverage, is acclaimed in the tropics for its numerous medicinal properties and antioxidant...

  • Role of Butea Frondosa in Ameliorating Gastric Markers in Induced Gastric Lesions of Rats. Banji, D.; Banji, Otilia J. F.; Singh, Meenu; Annamalai, A. R. // Indian Journal of Pharmaceutical Sciences;May/Jun2011, Vol. 73 Issue 3, p300 

    The study evaluated the ability of the alcohol extract of Butea frondosa to protect the gastro-duodenal lining from injury inflicted by acetic acid and pyloric ligation in rats. The induced gastric lesions lead to the generation of alkaline phosphatase and pepsin, which serve as important...

  • Malathion-induced hepatotoxicity in male Wistar rats: biochemical and histopathological studies. Flehi-Slim, Imen; Chargui, Issam; Boughattas, Sonia; Mabrouk, Aymen; Belaïd-Nouira, Yosra; Neffati, Fadwa; Najjar, Mohamed; Haouas, Zohra; Cheikh, Hassen // Environmental Science & Pollution Research;Nov2015, Vol. 22 Issue 22, p17828 

    The increasing use of organophosphorus pesticides in the environment constitutes an ecotoxicological hazard especially for humans and non-target animals. Hereby, we analyzed the toxic effects of malathion on the histological structure of liver and biochemical parameters in male rats. Three...

  • Three-Times-Weekly Administration of Teriparatide Improves Vertebral and Peripheral Bone Density, Microarchitecture, and Mechanical Properties Without Accelerating Bone Resorption in Ovariectomized Rats. Takao-Kawabata, Ryoko; Isogai, Yukihiro; Takakura, Aya; Shimazu, Yukari; Sugimoto, Emika; Nakazono, Osamu; Ikegaki, Ichiro; Kuriyama, Hiroshi; Tanaka, Shinya; Oda, Hiromi; Ishizuya, Toshinori // Calcified Tissue International;Aug2015, Vol. 97 Issue 2, p156 

    Daily and weekly administration of teriparatide (PTH) reduces the risk of osteoporotic bone fractures. However, their effects on markers of bone formation and bone resorption differ. These results indicate that the dosing frequency of teriparatide may affect bone metabolism and bone structure,...

  • Methodology developed for the simultaneous measurement of bone formation and bone resorption in rats based on the pharmacokinetics of fluoride. Lupo, Maela; Brance, Maria; Fina, Brenda; Brun, Lucas; Rigalli, Alfredo // Journal of Bone & Mineral Metabolism;Jan2015, Vol. 33 Issue 1, p16 

    This paper describes a novel methodology for the simultaneous estimation of bone formation (BF) and resorption (BR) in rats using fluoride as a nonradioactive bone-seeker ion. The pharmacokinetics of flouride have been extensively studied in rats; its constants have all been characterized. This...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics