TITLE

CARDIOPROTECTIVE EFFECTS OF LISINOPRIL IN STREPTOZOTOCIN INDUCED TYPE-II DIABETIC RATS

AUTHOR(S)
Parmar, K.; Prajapati, A.; Patel, S.; Patel, M.; Patel, B.
PUB. DATE
April 2012
SOURCE
Acta Endocrinologica (1841-0987);Apr-Jun2012, Vol. 8 Issue 2, p177
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim of the study. The objective of the present study was to determine the dose dependent effects of lisinopril, a ACE inhibitor on cardiovascular complications in streptozotocin induced diabetic rats. Materials and methods. Two days old neonatal pups (7-10 g) were used and they were made diabetic by intra-peritoneally (i.p.) injection of 90 mg/kg STZ in citrate buffer solution. Lisinopril was given orally at two different doses of 0.5 mg/kg/day and 3 mg/kg/day, p.o for 8 weeks. After 8 weeks treatment biochemical parameters from blood serum and hemodynamic parameters were analyzed. Results. The significant differences of glucose, insulin, cholesterol, triglyceride, creatinine kinase (CK-MB), lactate dehydrogenase (LDH), CRP level, left ventricular collagen content, cardiac hypertrophy index, left ventricular hypertrophy index in 3 mg/kg/day Lisinopril treated group compared to diabetic group were found. It showed a significant decrease in blood pressure compared to diabetic group. Conclusion. Lisinopril has beneficial effects on diabetes and its associated cardiovascular complications.
ACCESSION #
77415687

 

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