TITLE

Adeno-associated virus may play a protective role against human papillomavirus-induced cervical lesions independent of HIV serostatus

AUTHOR(S)
Bueno de Freitas, L.; Tonani de Mattos, A.; Lima, B. M. C.; Miranda, A. E.; Spano, L. C.
PUB. DATE
April 2012
SOURCE
International Journal of STD & AIDS;Apr2012, Vol. 23 Issue 4, p258
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study investigated the prevalence of adeno-associated virus (AAV) and human papillomavirus (HPV) DNA in cervical samples of HIV-seropositive and -seronegative women attending a clinic in south-eastern Brazil. Both viruses were investigated by polymerase chain reaction (PCR) and cytological exams were performed. AAV was typed by PCR and restriction fragment length polymorphism analysis. AAV prevalence was 19.7% (56/284), with 18.7% (21/112) and 20.3% (35/172) in HIV-positive and -negative women, respectively. AAV type 2 was the single virus type detected. AAV was detected with higher frequency in HPV- infected women (P < 0.05) as was HPV in HIV-positive women (P < 0.05). The AAV-HPV co-infected women showed a lower rate of atypical squamous cells of undetermined significance or cervical intraepithelial neoplasia development compared with those infected only with HPV. The prevalence of AAV2 confirms this type as the most common in human samples. This is the first report examining AAV in cervical samples of HIV-infected women and indicates that HIV infection does not appear to influence AAV prevalence or AAV-HPV co-infection.
ACCESSION #
77414570

 

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