TITLE

Formulation and evaluation of glipizide-loaded fast-dissolving tablets using husk of Plantago ovata as a superdisintegrant

AUTHOR(S)
Jha, Antesh Kumar; Chetia, Dipak
PUB. DATE
October 2011
SOURCE
Asian Journal of Pharmaceutics;2011, Vol. 5 Issue 4, p198
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The objective of the present study was to develop fast-dissolving tablets (FDTs) of glipizide, a sulfonylurea antidiabetic drug. The husk of Plantago ovata and pregelatinized husk of P. ovata were used as disintegrating agents. Microcrystalline cellulose was used as binder and starch (soluble) was used as bulk-forming agent. The powder blends were evaluated for angle of repose, compressibility index and Hausner ratio. The results of angle of repose, compressibility index (%) and Hausner ratio ranged from 24.23�0.57 to 29.34�0.78, 15.76�0.82 to 20.12�1.25 and 1.18�0.011 to 1.25�0.019, respectively. The tablet blends were converted into tablets by using direct compression method. The tablets were evaluated for disintegration test, hardness test, friability test, drug entrapment efficiency, content uniformity tests and drug release study. Formulations, which contained pregelatinized husk of P. ovata as a superdisintegrant, showed faster disintegration, higher percentage friability and lesser hardness than formulations containing husk of P. ovata as a superdisintegrant. Drug entrapment efficiency was found to be uniform among different batches of the tablets and ranged from 97.53�0.52 to 99.72�0.45. The results of content uniformity test of all the batches were found in the official range. The batches containing husk of P. ovata as a superdisintegrant released 15%--27% of glipizide per minute and those containing pregelatinized husk of P. ovata as a superdisintegrant released more than 95% of the drug within a minute. These results revealed that pregelatinized husk of P. ovata can be used as a superdisintegrant for obtaining FDTs.
ACCESSION #
77408891

Tags: DRUG development -- Research;  GLIPIZIDE (Drug);  PLANTAGO ovata;  CELLULOSE;  COMPRESSIBILITY;  TABLETS (Medicine)

 

Related Articles

  • Plantago ovata Mucilage in the Design of Fast Disintegrating Tablets. SHIRSAND, S. B.; SURESH, SARASIJA; PARA, M. S.; SWAMY, P. V.; KUMAR, D. NAGENDRA // Indian Journal of Pharmaceutical Sciences;2009, Vol. 71 Issue 1, p41 

    In the present work, fast disintegrating tablets of prochlorperazine maleate were designed with a view to enhance patient compliance by direct compression method. In this method mucilage of Plantago ovata and crospovidone were used as superdisintegrants (2-8% w/w) along with microcrystalline...

  • Comparative study on effect of natural and artificial superdisintegrants in the formulation of fast dissolving aspirin tablet. D.Yadav, Nikku; L.Pingale, Prashant; R.Tatane, Sagar // Journal of Pharmacy Research;Jul2010, Vol. 3 Issue 7, p1594 

    Aspirin is a salicylate drug and used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. In the present study, the effects of a natural superdisintegrants and synthetic superdisintegrants were compared in the formulations...

  • Studies on the Disintegrant properties of Mucilage and Seed Powder of Plantago ovata. Deveswaran, R.; Bharath, S.; Furtado, Sharon; Basavaraj, B. V.; Abraham, Sindhu; Madhavan, V. // International Journal of ChemTech Research;Jul2009, Vol. 1 Issue 3, p621 

    Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Dispersible tablets are intended to dissolve or disintegrate rapidly in the mouth for which various natural and synthetic disintegrants are included in the formulation. The study of...

  • FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF CARBAMAZEPINE USING NATURAL SUPERDISINTEGRANT PLANTAGO OVATA SEED POWDER AND MUCILAGE. Rao, N. G. Raghavemdra; Kulkarni, Upendra; Rao, K. Durga; Suresh, D. K. // International Journal of Pharmacy & Pharmaceutical Sciences;2010 Supplement 2, Vol. 2 Issue S2, p70 

    An attempt has been made for the development of fast dissolving tablets of the carbamazepine by wet granulation method, using different concentrations of natural superdisintegrating agent like plantego ovata seed powder and mucilage. The major problem of this drug is very low solubility in...

  • Design Optimization and Evaluation of Gastric Floating Matrix Tablet of Glipizide. Singh, Lalit; Nanda, Arun; Sharma, Saurabh; Sharma, Vijay // Tropical Journal of Pharmaceutical Research;Dec2013, Vol. 12 Issue 6, p869 

    Purpose: To formulate an optimized gastric floating drug delivery system (GFDDS) containing glipizide with carbomers and cellulosic polymers. Method: Central composite design (CCD) was employed in formulating the GFDDS using hydroxypropyl methylcellulose K4M (HPMC K4M) (A) and Carbopol 934P...

  • FORMULATION DEVELOPMENT STUDIES OF BILAYER TABLET GLIPIZIDE: A NOVEL AND EVOLUTIONARY APPROACH IN THE TREATMENT OF DIABETES. GUPTA, BIJANK; DEBNATH, RABINDRA; GHOSH, SOUMYADEEP; CHAKRABORTY, MANAS; BISWAS, AMITAVA // Asian Journal of Pharmaceutical & Clinical Research;Oct-Dec2013, Vol. 6 Issue 4, p131 

    Objective:The aim of present study is to formulate glipizide sustained release (SR) and immediate release (IR) bilayer matrix tablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and Ethyl Cellulose (EC) to control the release pattern. Method:The sustained release layer of...

  • Allergy risk from occupational exposure to herbal laxative.  // Reactions Weekly;9/17/2011, Issue 1369, p2 

    The article reports on a study which warns that prolonged occupational exposure to the powder of Plantago ovata seed products may cause allergic reactions.

  • Development of natural gum based fast disintegrating tablets of glipizide. Jha, Antesh Kumar; Chetia, Dipak // Asian Journal of Pharmaceutics;Oct-Dec2012, Vol. 6 Issue 4, p282 

    Dysphagia and risk of choking are leading causes of patient non-compliance in the self-administration of conventional tablets. To overcome these limitations of conventional tablets fast-disintegrating tablets were developed, using natural gums. Natural gums were evaluated for bulk swelling...

  • Effect of different polymers on release of the sustained release tablets of the glipizide. Thota Jaya Gouthami; Jhansipriya, M. V.; Naidu, N. // Journal of Chemical & Pharmaceutical Research;2013, Vol. 5 Issue 5, p111 

    Sustained release delivery systems have shown to be of better significance in release rate for drug. The present work was an attempt to study the effect of different polymers like HPMC - K100M, HPMC - K15M, Chitosan, and Aloe mucilage on release of the sustained release tablets of the Glipizide....

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics