Gastric emptying of liquids is delayed by co-ingesting solids: a study using salivary paracetamol concentrations

Sanaka, Masaki; Kuyama, Yasushi; Shimomura, Yuko; Qi, Jin Feng; Okamura, Shigeaki; Hao, Yu; Jainguo, Chen; Mineshita, Satoru
October 2002
Journal of Gastroenterology;2002, Vol. 37 Issue 10, p785
Academic Journal
Background. Paracetamol concentrations in plasma, a frequently used index of gastric emptying (GE) of liquids, are closely correlated with those in saliva. GE of liquids is delayed by co-ingesting solids. No researchers have used salivary paracetamol concentrations to show this phenomenon. The aim of this study was to elucidate whether salivary paracetamol concentrations can detect the food-induced delay in liquid GE. Methods. Paracetamol absorption was measured twice in five healthy male volunteers. Following an overnight fast, they received 10 mg/kg paracetamol in 200 ml water alone on one occasion, and received this solution after consuming a 400 kcal-containing cookie on another occasion. After thorough rinsing of the month, 1 ml saliva was obtained, simultaneously with 2 ml blood, at 0, 0.25, 0.5, 0.75, 1.0, 2.0, 3.0, 4.0, and 6.0 h after paracetamol intake. The peak concentration (C[sub max]), the time to C[sub max] (t[sub max]), the area under the curve (AUC), and C[sub max]/AUC in plasma were calculated. Salivary C[sub max] and t[sub max] were also determined. Results. Plasma C[sub max] and AUC were not significantly different between the two occasions. In contrast, significant differences in plasma t[sub max] and C[sub max]/ AUC (P < 0.05) established the food-induced delay in GE. Salivary t[sub max] could detect the delayed GE, whereas salivary C[sub max] could not. Conclusions. Salivary t[sub max] can document the solid meal-induced delay in liquid GE.


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