TITLE

No Association Between ick Gene Polymorphisms and Protein Level in Type 1 Diabetes

AUTHOR(S)
Nervi, Solange; Nicodeme, Sandra; Gartioux, Corinne; Atlan, Catherine; Lathrop, Marc; Reviron, Denis; Naquet, Philippe; Matsuda, Fumihiko; Imbert, Jean; Vialettes, Bernard
PUB. DATE
November 2002
SOURCE
Diabetes;Nov2002, Vol. 51 Issue 11, p3326
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We previously described a reduced expression of the protein tyrosine kinase Lck in T-cells from type 1 diabetic patients, the origin of which is still unknown. The human lck gene, located on chromosome 1p35-34.3, was evaluated as a candidate susceptibility gene for type 1 diabetes. A molecular scan of the sequence variations in the coding, the relevant promoter, and most of the intronic sequences of the lck gene (representing a total of 10.5 kb fragment) was performed in 187 Caucasian subjects including 91 type 1 diabetic patients and 96 normoglycemic control subjects. We identified 35 sequence variations, including one deletion and 34 single nucleotide polymorphisms (SNPs), 33 of them being new. Four variants were frequent but not significantly associated with diabetes or Lck protein level. Of the SNP variants, 11 were only found within the diabetic population and some were associated with low Lck protein levels. The low frequency of these polymorphisms did not permit any statistically significant cotrelations with the disease status, suggesting that the lck gene probably does not contribute to genetic susceptibility to type 1 diabetes.
ACCESSION #
7726794

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics