TITLE

Occasion Setting and Drug Tolerance

AUTHOR(S)
Ramos, Barbara M.C.; Siegel, Shepard; Bueno, Jose Lino O.
PUB. DATE
July 2002
SOURCE
Integrative Physiological & Behavioral Science;Jul-Sep2002, Vol. 37 Issue 3, p165
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
There is considerable evidence that drug-paired cues become associated with drug effects. It has been hypothesized that these cues act as Pavlovian conditional stimuli (CSs), and elicit conditional compensatory responses that contribute to tolerance. On the basis of a conditioning analysis of tolerance, we would expect that it should be possible to establish drug-paired cues as occasion setters, as well as conditional stimuli. Using feature-positive discrimination training, we evaluated the contribution of occasion-setting stimuli (as well as CSs) to tolerance to the hypothermic effect of ethanol in rats. The results indicated that a complete associative analysis of drug tolerance should incorporate not only the CS properties of predrug cues, but also the occasion-setting properties of such cues. The findings have implications for interpreting conflicting findings concerning extinction of tolerance and for cue-exposure treatments of addiction.
ACCESSION #
7707582

 

Related Articles

  • Conditioned place preference: what does it add to our preclinical understanding of drug reward? Bardo, M.T.; Bevins, R.A. // Psychopharmacology;2000, Vol. 153 Issue 1, p31 

    Abstract Rationale: Among the various experimental protocols that have been used to measure drug reward in laboratory animals, conditioned place preference (CPP) has been one of the most popular. However, a number of controversial issues have surrounded the use of this experimental protocol....

  • Stimulus Properties of Nicotine, Amphetamine, and Chlordiazepoxide as Positive Features in a Pavlovian Appetitive Discrimination Task in Rats. Palmatier, Matthew I.; Wilkinson, Jamie L.; Metschke, Dawn M.; Bevins, Rick A. // Neuropsychopharmacology;Apr2005, Vol. 30 Issue 4, p731 

    Recent experiments from our laboratory have demonstrated that drug states can signal when environmental cues will be followed by rewarding outcomes (ie Pavlovian conditioning). However, little is known about the generality of this approach and whether it can be used for studying the...

  • The effect of nicotine on sign-tracking and goal-tracking in a Pavlovian conditioned approach paradigm in rats. Palmatier, Matthew; Marks, Kimberley; Jones, Scott; Freeman, Kyle; Wissman, Kevin; Sheppard, A. // Psychopharmacology;Mar2013, Vol. 226 Issue 2, p247 

    Rationale: Nicotine (NIC) potently increases operant responding for non-NIC reinforcers, and this effect may depend on drug-mediated increases in incentive motivation. According to this hypothesis, NIC should also potently increase approach to Pavlovian-conditioned stimuli associated with...

  • Pavlovian conditioned approach, extinction, and spontaneous recovery to an audiovisual cue paired with an intravenous heroin infusion. Peters, Jamie; Vries, Taco // Psychopharmacology;Jan2014, Vol. 231 Issue 2, p447 

    Rationale: Novel stimuli paired with exposure to addictive drugs can elicit approach through Pavlovian learning. While such approach behavior, or sign tracking, has been documented for cocaine and alcohol, it has not been shown to occur with opiate drugs like heroin. Most Pavlovian conditioned...

  • The Pavlovian `principle of strength'. Windholz, George // Integrative Physiological & Behavioral Science;Jul-Sep95, Vol. 30 Issue 3, p228 

    Discusses the Pavlovian principle of strength which assumes that the magnitude of the conditional response is a linear function of the intensity of the external conditional stimulus. Initial observations and formulations of the principle of strength; Experiments supporting the principle of...

  • Blocking and unconditioned response diminution in human classical autonomic conditioning. Kimmel, H.D.; Bevill, M.J. // Integrative Physiological & Behavioral Science;Jan-Mar96, Vol. 31 Issue 1, p18 

    Examines blocking and unconditioned response (UR) diminution in human classical autonomic conditioning. Insignificance of the correlation between blocking and UR diminution; Details on differential conditioning procedure used; Importance of repeated nonreinforced test trials for blocking.

  • Abstracts from the annual meeting of the Pavlovian society.  // Integrative Physiological & Behavioral Science;Apr-Jun97, Vol. 32 Issue 2, p180 

    Presents an abstract of the research `Renal Sympathetic Nerve Recordings During Classical Conditioning Predict Arterial Blood Pressure Response to CS+ and CS-,' by D.E. Burgess, D.C. Randall, et al, presented at the annual meeting of the Pavlovian Society held in Baltimore, Maryland, on November...

  • Abstracts from the annual meeting of the Pavlovian society.  // Integrative Physiological & Behavioral Science;Apr-Jun97, Vol. 32 Issue 2, p191 

    Presents an abstract of the research `The Stress-Induced Facilitation of Pavlovian Conditioning: An Update on Behavioral Characteristics and Brain Substrates,' by Tracey J. Shors presented at the annual meeting of the Pavlovian Society held in Baltimore, Maryland, on November 14-16, 1996.

  • Electrodermal Pavlovian conditioning with prepared and unprepared stimuli. Kirsch, Peter; Boucsein, Wolfram // Integrative Physiological & Behavioral Science;Apr-Jun94, Vol. 29 Issue 2, p134 

    Discusses the results of a study on electrodermal Pavlovian conditioning with prepared and unprepared stimuli. Use of electrodermal activity and probe reaction times to measure conditioning; Emergence of conditional stimuli and unconditional stimulus contingency learning in the indicators.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics