TITLE

Prevalence, Haemolytic Activities and Flouroquinolones Susceptibility Profiles of Moraxella catarrhalis, Streptococcus pneumoniae and Haemophilus influenzae Associated with Acute Otitis Media

AUTHOR(S)
Joseph, Akinjogunla Olajide; Odeh, Eghafona Nosakhare
PUB. DATE
June 2011
SOURCE
Nature & Science;Jun2011, Vol. 9 Issue 6, p85
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study was designed to determine the prevalence, haemolytic activities and flouroquinolones susceptibility profiles of Moraxella catarrhalis, Streptococcus pneumoniae and Haemophilus influenzae associated with acute otitis media. 272 middle-ear swabbed samples were aseptically collected and analyzed using standard microbiological and disk diffusion methods for antibiotic susceptibility. Haemolytic activities were determined using blood agar. Significant difference at (p<0.05) was observed among 124 (45.6%) male patients and 148 (54.4%) female patients with acute otitis media. 51(18.8%) Moraxella catarrhalis, 58 (21.3%) Haemophilus influenzae and 47(17.3) Streptococcus pneumoniae were identified. The flouroquinolones susceptibility of these bacteria showed that 80-84% of the Moraxella catarrhalis were sensitive to ciprofloxacin, levofloxacin and moxifloxacin, while 29.4% of Moraxella catarrhalis were resistant to ofloxacin. The resistance rate of Streptococcus pneumoniae to the flouroquinolones varied from 29.8 % for levofloxacin to 42.6% for ciprofloxacin. 42 (26.9%) of the isolates were resistant to at least 2 antibiotics with multiple antibiotics resistance index ranging between 0.25 to 0.75 in Moraxella catarrhalis and 0.25 to 1.00 in both Haemophilus influenzae and Streptococcus pneumoniae . Haemolytic activities of these isolates showed that for Moraxella catarrhalis, 7 strains (13.7%) showed α-haemolysis, 27 (52.9%) β- haemolysis, and (α + β) hemolysis occurred in 3 (5.9%). Haemophilus influenzae and Streptococcus pneumoniae showed 9 (15.5%), 28 (59.6%) α-haemolysis, respectively. Haemophilus influenzae also showed 21 (36.2%), 2 (3.4%) and 26 (44.8%) β, α + β and γ. respectively, while 3 (6.4%) Streptococcus pneumoniae showed β- haemolysis. Despite the effectiveness of flouroquinolones especially levofloxacin and moxifloxacin against these bacterial isolates, prudent use of the antibiotics is strongly recommended.
ACCESSION #
76551152

 

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