TITLE

Possible Accelerated Approval Path 'EMERGE[s]' for CDX-011

AUTHOR(S)
Boggs, Jennifer
PUB. DATE
May 2012
SOURCE
BioWorld Today;5/25/2012, p1
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
The article reports that Celldex Therapeutics has been considering an accelerated approval pathway for its glycoprotein NMB (GPNMB)-targeting antibody-drug conjugate CDX-011 after a preliminary Phase IIb data showed high response rates. According to the trial, the response rate of cancer patients with high GPNMB levels in the treatment group was 32%. Anthony Marucci of Celldex claims that the company has a reliable assay. A strong disease control was also shown by data from the trial.
ACCESSION #
76475194

Tags: DRUG approval;  CELLDEX Therapeutics Inc.;  ANTIBODY-drug conjugates;  GLYCOPROTEINS;  CLINICAL trials;  CANCER -- Patients;  MARUCCI, Anthony

 

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