A DSC study of paeonol-encapsulated liposomes, comparison the effect of cholesterol and stigmasterol on the thermotropic phase behavior of liposomes

Wu, Rui-Guang; Wang, Yu-Rong; Wu, Fu-Gen; Zhou, Hong-Wei; Zhang, Xiao-Hua; Hou, Jun-Ling
July 2012
Journal of Thermal Analysis & Calorimetry;Jul2012, Vol. 109 Issue 1, p311
Academic Journal
Thermotropic phase behaviors of paeonol-encapsulated liposomes containing stigmasterol or cholesterol have been investigated by differential scanning calorimetry. We compared the thermotropic phase behavior of pure dipalmitoylphosphatidylcholine (DPPC) liposomes, sterol/DPPC liposomes, and paeonol/sterol/DPPC liposomes increasing the ratio of paeonol to sterol from 0 to 1, by analyzing the calorimetric parameters of main phase transition of liposomes including phase transition temperature (onset temperature and peak temperature) and phase transition cooperativity. The results showed that paeonol could incorporate into the hydrophobic region of DPPC, thus, decrease phase transition temperature of DPPC. Though stigmasterol interacts with DPPC less favorably than cholesterol, thermotropic phase behavior of paeonol/cholesterol/DPPC liposomes and that of paeonol/stigmasterol/DPPC liposomes are very similar. A phase separation occurred when the molar ratio of paeonol to sterol reached 1:1 in paeonol-encapsulated liposomes, where a paeonol-rich domain coexisted with a sterol-rich domain. The packing order of acyl chains of DPPC in sterol-rich domain is a little higher than that in paeonol-rich domain.


Related Articles

  • Comparative Analysis of the Effect of the Nature of the Filler on Spontaneous Polymerization of the Binder in Prepregs. Khaskov, M. // Fibre Chemistry;May2015, Vol. 47 Issue 1, p24 

    We have used differential scanning calorimetry to study the effect of the nature of the filler (carbon and aramid fibres, fibreglass) on spontaneous polymerization of prepregs based on ÉDT69n epoxy binder. In order to evaluate the effect, we used the change in the glass transition...

  • Comparative studies of regenerated water-based Mori, Thai, Eri, Muga and Tussah silk fibroin films. Wang, Fang; Wolf, Nathan; Rocks, Eva-Marie; Vuong, Trinh; Hu, Xiao // Journal of Thermal Analysis & Calorimetry;Dec2015, Vol. 122 Issue 3, p1069 

    Silk materials from different silkworm species can be utilized in various medical and material applications. In this study, five types of silk proteins: Indian Antheraea mylitta (Tussah), Philosamia ricini (Eri), Antheraea assamensis (Muga), Thailand and Chinese Bombyx mori mulberry (Thai, Mori)...

  • Environmental ageing of aerospace epoxy adhesive in bonded assembly configuration. Causse, Nicolas; Dantras, Eric; Tonon, Claire; Chevalier, Mathieu; Combes, Hélène; Guigue, Pascale; Lacabanne, Colette // Journal of Thermal Analysis & Calorimetry;Nov2013, Vol. 114 Issue 2, p621 

    Aerospace epoxy adhesive has been subjected to various environmental ageing processes. A comparative study is performed between ageing under vacuum and atmospheric pressure for various ageing temperatures. The macroscopic behaviour of the assemblies is investigated by single lap shear test....

  • A MATTER OF TIME. Gagro, Damir // European Coatings Journal;2015, Issue 11, p3 

    An introduction is presented in which the editor discusses various reports within the issue on topics including standards for evaluating characteristics of a coating, the use of differential scanning calorimetry (DSC) as a tool for powder coatings quality control, and glass transition temperature.

  • Crystallization kinetics and miscibility of blends of polyhydroxybutyrate (PHB) with ethylene vinyl acetate copolymers (EVA). El-Taweel, S. H.; Stoll, B.; Schick, C. // e-Polymers;Mar2011, p1 

    A series of ethylene vinyl acetate random copolymer EVA, with vinyl acetate (VA) varied from 9 to 91m%, was investigated by differential scanning calorimetry DSC and polarized optical microscopy. Biodegradable polymer blends of polyhydroxybutyrate PHB and EVA, having VA in EVA in range from 40m%...

  • Comparative investigation on the enthalpy relaxation of four amorphous pentose isomers. Gao, Cai; Ye, Bin; Jiang, Bin; Liu, Xiang-Nong // Journal of Thermal Analysis & Calorimetry;Jan2014, Vol. 115 Issue 1, p37 

    The enthalpy relaxation of the pentose isomers ( d-xylose, d-ribose, l-arabinose, and d-arabinose) was investigated in terms of the Tool-Narayanaswamy-Moynihan and Adam-Gibbs-Vogel models using differential scanning calorimetry. Single set of parameters for each model was obtained from the...

  • Interaction of resveratrol analogues with biomembrane models: a calorimetric study on structural variations effects. Sarpietro, Maria Grazia; Spatafora, Carmela; Ottimo, Sara; Tringali, Corrado; Castelli, Francesco // Journal of Excipients & Food Chemicals;Sep2012, Vol. 3 Issue 3, p96 

    Differential Scanning Calorimetry was used to study the interaction of new resveratrol derivatives using dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV) as biomembrane models. MLV prepared in the presence of increasing molar fractions of the following compounds: (A)...

  • Membrane Fusion between Liposomes Composed of Acidic Phospholipids and Neutral Phospholipids Induced by Melittin: A Differential Scanning Calorimetric Study1. Higashino, Yukako; Matsui, Akira; Ohki, Kazuo // Journal of Biochemistry;2001, Vol. 130 Issue 3, p393 

    Melittin-induced membrane fusion between neutral and acidic phospholipids was examined in liposome systems with a high-sensitivity differential scanning calorimeter. Membrane fusion could be detected by calorimetric measurement by observing thermograms of mixed liposomal lipids. The roles of...

  • Integration of Quercetin-Iron Complexes into Phosphatidylcholine or Phosphatidylethanolamine Liposomes. Kim, Yuri; Tarahovsky, Yury; Yagolnik, Elena; Kuznetsova, Svetlana; Muzafarov, Eugeny // Applied Biochemistry & Biotechnology;Aug2015, Vol. 176 Issue 7, p1904 

    It is well known that flavonoids can chelate transition metals. Flavonoid-metal complexes exhibit a high antioxidative and therapeutic potential. However, the complexes are frequently hydrophobic ones and low soluble in water, which restricts their medical applications. Integration of these...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics