Synthesis and preclinical pharmacological evaluation of a novel Tc-shikonin as a potential tumor imaging agent

Motaleb, M.; Al-Musayeib, N.; Zaghary, W.; Shweeta, H.
July 2012
Journal of Radioanalytical & Nuclear Chemistry;Jul2012, Vol. 293 Issue 1, p391
Academic Journal
Shikonin was isolated from Ratanjot pigment then the obtained shikonin was well characterized. This study is aimed to optimize radiolabeling yield of shikonin with Tc with respect to factors that affect the reaction conditions such as shikonin amount, SnCl·2HO amount, reaction time and pH of the reaction mixture. In vitro stability of the radiolabeled complex was checked and it was found to be stable for up to 6 h. Biodistribution studies showed that, Tc-shikonin accumulate in tumor sites with higher T/NT than other currently available Tc(CO)-VIP, Tc-nitroimidazole analogues and Tc-polyamine analogues indicating that shikonin deliver Tc to the tumor sites with a percentage sufficient for imaging and can overcome many drawbacks of other radiopharmaceuticals used for tumor imaging .


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