Trace amine receptor ligands: tritiation at high specific activity

Ahern, David; Orphanos, Demetri; Filer, Crist
July 2012
Journal of Radioanalytical & Nuclear Chemistry;Jul2012, Vol. 293 Issue 1, p415
Academic Journal
d-amphetamine and tyramine are both amines which are active at the recently discovered trace amine-associated receptor 1 (TAAR1) and analogues of these compounds labelled with tritium would be useful reagents for neurochemistry investigators. This paper describes the tritiation and characterization of these substances. d-amphetamine was radiolabelled by a direct tritium catalytic method and characterized by proton decoupled tritium NMR. For tyramine, a bromination-catalytic tritium debromination approach worked best to afford a tritiated analogue at high specific activity.


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