TITLE

Direct labeling of doxorubicin with technetium-99m: its optimization, characterization and quality control

AUTHOR(S)
Rizvi, Faheem; Bokhari, Tanveer; Roohi, S.; Mushtaq, A.
PUB. DATE
July 2012
SOURCE
Journal of Radioanalytical & Nuclear Chemistry;Jul2012, Vol. 293 Issue 1, p303
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Doxorubicin (DOX) is an anthracycline antineoplastic and one of the most potent and widely used drugs in clinical oncology. It is used in the treatment of a wide variety of cancers. The aim of this study was the direct labeling of DOX with Tc; its optimization, characterization and quality control of the radiolabeled DOX. Labeling efficiency was determined by paper chromatography. More than 92% labeling was obtained at pH 6-7, 10-12 μg stannous chloride and 200 μg of DOX. The stability of Tc-DOX was studied up to 5 h. All the experiments were performed at room temperature (25± 2 °C). The characterization of the labeling compound was performed by HPLC and electrophoresis. Electrophoresis indicates that labeled DOX has no charge and HPLC shows single specie of labeled compound.
ACCESSION #
76447087

 

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