Age-related cardiovascular disease and the beneficial effects of calorie restriction

Sung, Miranda; Dyck, Jason
September 2012
Heart Failure Reviews;Sep2012, Vol. 17 Issue 4/5, p707
Academic Journal
Aging is a well-recognized risk factor in the development of cardiovascular disease, which is the primary cause of death and disability in the elderly population. The normal process of aging is associated with progressive deterioration in structure and function of the heart and vasculature. These age-related changes likely act as both a catalyst and accelerator in the development of cardiovascular disease. Since the aging population is one of the fastest growing segments of the population, it is of vital importance that we have a thorough understanding of the physiological changes that occur with aging that contribute to the high incidence of cardiovascular disease in this population. This insight will allow for the development of more targeted therapies that can prevent and treat these conditions. One such anti-aging strategy that has received considerable attention as of late is calorie restriction. Calorie restriction has emerged as one of the most effective and reproducible interventions for extending lifespan, as well as protecting against obesity, metabolic disorders, and cardiovascular disease. Herein, we review the multiple beneficial effects that calorie restriction and resveratrol exert on the cardiovascular system with a particular focus on aging. Although calorie restriction and resveratrol have proven to be very effective in preventing and treating the development of cardiovascular disease in animal models, studies continue as to whether these profound beneficial effects can translate to humans to improve cardiovascular health.


Related Articles

  • CARDIOVASCULAR DISEASE COULD BE CONTAINED BASED ON CURRENTLY AVAILABLE DATA! Ofodile, Okom Nkili F. C. // Dose-Response;2006, Vol. 4 Issue 3, p225 

    Largely due to better control of infectious diseases and significant advances in biomedical research, life expectancy worldwide has increased dramatically in the last three decades. However, as the average age of the population has risen, the incidence of chronic age-related diseases such as...

  • A comment on the comment: relevance of nonhuman primate dietary restriction to aging in humans. Bodkin, Noni L.; Ortmeyer, Heidi K.; Hansen, Barbara C. // Journals of Gerontology Series A: Biological Sciences & Medical ;Aug2005, Vol. 60 Issue 8, p951 

    Presents a reply to a commentary on a study on the effect of dietary restriction on age-related diseases and physiological function during the aging process. Overview of the study; Calorie requirements of primates, both nonhuman and human; Description of the monkeys used in the study.

  • Medicinal Chemistry of the Epigenetic Diet and Caloric Restriction. Martin, S. L.; Hardy, T. M.; Tollefsbol, T. O. // Current Medicinal Chemistry;Oct2013, Vol. 20 Issue 32, p4050 

    The pronounced effects of the epigenetic diet (ED) and caloric restriction (CR) have on epigenetic gene regulation have been documented in many pre-clinical and clinical studies. Understanding epigenetics is of high importance because of the concept that external factors such as nutrition and...

  • Newer antidiabetic drugs and calorie restriction mimicry. Kalra, Sanjay; Jacob, Jubbin Jagan; Gupta, Yashdeep // Indian Journal of Endocrinology & Metabolism;Jan/Feb2016, Vol. 20 Issue 1, p142 

    De-acceleration of aging and delayed development of age-related morbidity accompanies the restriction of calories (without malnutrition) in laboratory mice, nematodes, yeast, fish, and dogs. Recent results from long-term longitudinal studies conducted on primates have suggested longevity...

  • The Fountain of Health. Rotman, David // Technology Review;Mar/Apr2006, Vol. 109 Issue 1, p72 

    The article discusses research on the anti-aging and health benefits of calorie-restricted diets. Calorie restriction delays the onset of a broad spectrum of age-related diseases. The idea that the genetic and molecular causes of aging and of many diseases are connected could provide a powerful...

  • Caloric restriction and heart function: is there a sensible link? Xuefeng Han; Ren, Jun // Acta Pharmacologica Sinica;Sep2010, Vol. 31 Issue 9, p1111 

    Calorie restriction (CR) is defined as a reduction in calorie intake below the usual ad libitum intake without malnutrition. Ample of clinical and experimental evidence has demonstrated that CR is capable of retarding aging process and development of cardiovascular disease. Although suppression...

  • A More Wholistic Answer To Neonics Needed. SULECKI, JIM // Greenhouse Grower;Dec2014, p8 

    The article offers information related to the Meister Media Worldwide's Biocontrols 2015 Tradeshow and Conference to be held on March 3-5, 2015 in Fresno, California.

  • MODULATION OF AGE-RELATED PATHOLOGY BY CALORIE RESTRICTION AND VOLUNTARY EXERCISE IN MALE FISCHER 344 RATS. Ikeno, Y.; McCarter, R. J. M.; Hubbard, G. B.; Bertrand, H. A.; Lee, S.; Yu, B. P. // Gerontologist;Oct1996 Supplement, Vol. 36 Issue 1, p166 

    The life-extending effect of calorie restriction (CR) and the beneficial effect of voluntary exercise (E) are well known. However, only a few systematic studies have addressed the life-long effects of CR and E on age-related disease. To explore the effects of both CR and E on age-related disease...

  • Swimming T-Maze and Radial Maze: two Cognitive Procedural Experiments to Determine the Influence of Acute Calorie Restriction over Learning Abilities in Wistar Rats. Mănălăchioae, Radu; Sarpataki, Orsolya; Prodan, Iulia; Sevastre, Bogdan; Marcus, Ioan // Bulletin of the University of Agricultural Sciences & Veterinary;2011, Vol. 68 Issue 1, p213 

    Caloric restriction (CR) has long been known to increase median and maximal lifespan and to decreases mortality and morbidity in short-lived animal models, likely by altering fundamental biological processes that regulate aging and longevity. In rodents, CR was reported to delay the aging of the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics