TITLE

Facile synthesis of some novel 2-substituted-4,6- diarylpyrimidines using 4'-hydroxy-3',5'-dinitrochalcones and Sbenzylthiouronium chloride

AUTHOR(S)
Ameta, K. L.; Kumar, Biresh; Rathore, Nitu S.; Verma, B. L.
PUB. DATE
January 2012
SOURCE
Organic Communications;Jan-Mar2012, Vol. 5 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Various 4'-hydroxy-3',5'-dinitro substituted chalcones 1 and S-benzylthiouronium chloride (SBT) 2 in the presence of DMF-organic bases (morpholine/ pyrrolidine/ piperidine) gave 4,6-diaryl-2-(4-morpholinyl / 1- pyrrolidinyl /1-piperidinyl)- pyrimidines 4, 5 and 6 in a facile one-pot conversion. In an another attempt reactants 1 and 2 yielded intermediate 2-benzylthiopyrimidines 3, in presence of DMF, which on treatment with heterocyclic secondary amines gave products 4, 5 and 6 in an alternate two-step process.
ACCESSION #
76386828

 

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