Preparation and characterization of biodegradable cefpodoxime proxetil nanocapsules

Muratkar, Dhiraj; Untwal, Lakshya; Naik, Jitendra
February 2012
Asian Journal of Pharmaceutical Sciences;2012, Vol. 7 Issue 1, p143
Academic Journal
Owing to poor water solubility, drugs such as cefpodoxime proxetil show poor dissolution characteristics and in turn poor oral bioavailability. The aim of present study was to formulate biodegradable cefpodoxime proxetil nanocapules by interfacial deposition technique using poly-(D,L-lactic acid) (PLA) as polymer and to evaluate the prepared nanocapsules. PLA was selected as biodegradable polymer for the preparation after careful compatibility study between drug and polymer. The drug: polymer ratio and process were modified to get encapsulation efficiency of nearly 94%. Characterization shows that the prepared nanocapsules had round to oval shape with particle size in the range of 40-400 nm and a zeta potential of -50 ± 2 mV. In vitro drug release study shows that the prepared nanocapsules possess sustained release properties.


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