TITLE

Immune Response Against Sporothrix schenckii in TLR-4-Deficient Mice

AUTHOR(S)
Sassá, Micheli; Ferreira, Lucas; Abreu Ribeiro, Livia; Carlos, Iracilda
PUB. DATE
July 2012
SOURCE
Mycopathologia;Jul2012, Vol. 174 Issue 1, p21
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
For many fungal diseases, macrophages are the major cell population implicated in host protection, primarily by their ability to eliminate the invading fungal pathogen through phagocytosis. In sporotrichosis, this remains true, because of macrophages' ability to recognize Sporothrix schenckii through specific receptors for some of the fungus' cellular surface constituents. Further confirmation for macrophages' pivotal role in fungal diseases came with the identification of toll-like receptors, and the subsequent numerous associations found between TLR-4 deficiency and host susceptibility to diverse fungal pathogens. Involvement of TLR-4 in immune response against sporotrichosis has been conducted to investigate how TLR-4 signaling could affect inflammatory response development through evaluation of HO production and IL-1β, IL-6 and TGF-β release during the course of S. schenckii infection on TLR-4-deficient mice. The results showed that macrophages are largely dependent on TLR-4 for inflammatory activation and that in the absence of TLR-4 signaling, increased TGF-β release may be one of the contributing factors for the abrogated inflammatory activation of peritoneal exudate cells during mice sporotrichosis.
ACCESSION #
76350961

 

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