Immune Response Against Sporothrix schenckii in TLR-4-Deficient Mice

Sassá, Micheli; Ferreira, Lucas; Abreu Ribeiro, Livia; Carlos, Iracilda
July 2012
Mycopathologia;Jul2012, Vol. 174 Issue 1, p21
Academic Journal
For many fungal diseases, macrophages are the major cell population implicated in host protection, primarily by their ability to eliminate the invading fungal pathogen through phagocytosis. In sporotrichosis, this remains true, because of macrophages' ability to recognize Sporothrix schenckii through specific receptors for some of the fungus' cellular surface constituents. Further confirmation for macrophages' pivotal role in fungal diseases came with the identification of toll-like receptors, and the subsequent numerous associations found between TLR-4 deficiency and host susceptibility to diverse fungal pathogens. Involvement of TLR-4 in immune response against sporotrichosis has been conducted to investigate how TLR-4 signaling could affect inflammatory response development through evaluation of HO production and IL-1β, IL-6 and TGF-β release during the course of S. schenckii infection on TLR-4-deficient mice. The results showed that macrophages are largely dependent on TLR-4 for inflammatory activation and that in the absence of TLR-4 signaling, increased TGF-β release may be one of the contributing factors for the abrogated inflammatory activation of peritoneal exudate cells during mice sporotrichosis.


Related Articles

  • Effects of human Toll-like receptor 1 polymorphisms on ageing. Uciechowski, Peter; Oellig, Eva Maria; Mariani, Erminia; Malavolta, Marco; Mocchegiani, Eugenio; Rink, Lothar // Immunity & Ageing;2013, Vol. 10, p1 

    Background: Advanced age results in crucial alterations of the innate and adaptive immune system leading to functional defects resulting in infection and chronic diseases. Toll-like receptors (TLR) recognize pathogenic structures and are important in the immune response to infections and...

  • Interleukin 1 Receptor–Associated Kinase M Impairs Host Defense During Pneumococcal Pneumonia. van der Windt, Gerritje J. W.; Blok, Dana C.; Hoogerwerf, Jacobien J.; Lammers, Adriana J. J.; de Vos, Alex F.; van't Veer, Cornelis; Florquin, Sandrine; Kobayashi, Koichi S.; Flavell, Richard A.; van der Poll, Tom // Journal of Infectious Diseases;Jun2012, Vol. 205 Issue 12, p1849 

    Background. Streptococcus pneumoniae is the most common causative organism in community-acquired pneumonia. Pneumococci that try to invade the lower airways are recognized by innate immune cells through pattern recognition receptors, including Toll-like receptors 2, 4, and 9. Interleukin 1...

  • Bioinformatics Analysis of the FREM1 Geneô€‚²Evolutionary Development of the IL-1R1 Co-Receptor, TILRR. Hudson, Richard C.; Gray, Caroline; Kiss-Toth, Endre; Chico, Timothy J. A.; Qwarnstrom, Eva E. // Biology (2079-7737);Dec2012, Vol. 1 Issue 3, p484 

    The TLRs and IL-1 receptors have evolved to coordinate the innate immune response following pathogen invasion. Receptors and signalling intermediates of these systems are generally characterised by a high level of evolutionary conservation. The recently described IL-1R1 co-receptor TILRR is a...

  • Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Greiff, Lennart; Cervin, Anders; Ahlström-Emanuelsson, Cecilia; Almqvist, Gun; Andersson, Morgan; Dolata, Jan; Eriksson, Leif; Högestätt, Edward; Källén, Anders; Norlén, Per; Sjölin, Inga-Lisa; Widegren, Henrik // Respiratory Research;Jun2012, Vol. 13 Issue 6, p1 

    Background: Interactions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential as a treatment for allergic airway disease by skewing the immune system away from a Th2 profile....

  • TIR8/SIGIRR is an interleukin-1 receptor/toll like receptor family member with regulatory functions in inflammation and immunity. Riva, Federica; Bonavita, Eduardo; Barbati, Elisa; Muzio, Marta; Mantovani, Alberto; Garlanda, Cecilia // Frontiers in Immunology;Oct2012, Vol. 3, p1 

    Interleukin-1R like receptors (ILRs) and Toll Like Receptors (TLRs) are key receptors of innate immunity, inflammation, and orientation of the adaptive response. They belong to a superfamily characterized by the presence of a conserved intracellular domain, the Toll/IL-1R (TIR) domain, which is...

  • Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells. Redlich, Sandra; Ribes, Sandra; Schütze, Sandra; Eiffert, Helmut; Nau, Roland // Journal of Neuroinflammation;2013, Vol. 10 Issue 1, p1 

    Background: Toll-Like receptors (TLRs) belong to the family of pattern-recognition receptors with a crucial function of recognising pathogen-associated molecular patterns (PAMPs). Cryptococcal meningitis is a potentially fatal disease with a high mortality and risk of neurological sequelae....

  • Molecular cloning and functional characterization of murine toll-like receptor 8. TINGTING LI; XIAOBING HE; HUAIJIE JIA; GUOHUA CHEN; SHUANG ZENG; YONGXIANG FANG; QIWANG JIN; ZHIZHONG JING // Molecular Medicine Reports;2016, Vol. 13 Issue 2, p1119 

    Toll-like receptors (TLRs) are a large family of germ-line encoded pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns and evoke the relevant innate immune responses. TLR8 is a member of several endosome nucleic acid-sensing TLRs; however little attention...

  • Comprehensive Logic Based Analyses of Toll-Like Receptor 4 Signal Transduction Pathway. Padwal, Mahesh Kumar; Sarma, Uddipan; Saha, Bhaskar // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Among the 13 TLRs in the vertebrate systems, only TLR4 utilizes both Myeloid differentiation factor 88 (MyD88) and Toll/Interleukin-1 receptor (TIR)-domain-containing adapter interferon-β-inducing Factor (TRIF) adaptors to transduce signals triggering host-protective immune responses. Earlier...

  • Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment. Singhal, Gaurav; Jaehne, Emily J.; Corrigan, Frances; Baune, Bernhard T. // Frontiers in Cellular Neuroscience;2014, Vol. 8, p1 

    Recent studies on environmental enrichment (EE) have shown cytokines, cellular immune components [e.g., T lymphocytes, natural killer (NK) cells], and glial cells in causal relationship to EE in bringing out changes to neurobiology and behavior. The purpose of this reviewis to evaluate these...


Read the Article

Courtesy of

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics