TITLE

Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet

AUTHOR(S)
Raja, Boobalan; Saravanakumar, Murugesan; Sathya, Gopal
PUB. DATE
July 2012
SOURCE
Molecular & Cellular Biochemistry;Jul2012, Vol. 366 Issue 1/2, p21
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An investigation was made to reveal the protective effects of veratric acid (VA), a phenolic acid against atherogenic diet-induced hyperlipidemic rats. Male albino Wistar rats were fed with atherogenic diet (4% cholesterol, 1% cholic acid, and 0.5% 2-thiouracil) daily for 30 days and treated with VA (40 mg/kg body weight) daily for a period of 30 days. Rats fed with atherogenic diet showed significant ( P < 0.05) elevation in the level of plasma lipids, systolic and diastolic blood pressure, oxidative stress markers (thiobarbituric acid reactive substances, lipid peroxides) and significant ( P < 0.05) reduction in the activities of enzymatic (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (vitamin C, vitamin E, and reduced glutathione) antioxidants in erythrocytes, plasma, and tissues (liver, kidney, and aorta). Oral administration of VA (40 mg/kg body weight) for 30 days to atherogenic diet fed rats markedly attenuates systolic, diastolic blood pressure and lipid peroxidation products. Further, VA treatment significantly improved enzymatic and non-enzymatic antioxidants levels and showed beneficial effects on lipid profile in atherogenic diet rats. All the above alterations were supported by histopathological observations. These results indicate that oral administration of VA ameliorates atherogenic diet-induced hyperlipidemia in rats by its free radical scavenging; improving the antioxidants and lipid lowering properties.
ACCESSION #
76350948

 

Related Articles

  • The antioxidant myth. Melton, Lisa // New Scientist;8/5/2006, Vol. 191 Issue 2563, p40 

    The article discusses the health benefits and risks of taking antioxidant supplements. The author explains that antioxidants are believed to fight against free radicals by adding an extra electron to their composition. The article shows evidence from various studies that have found antioxidants...

  • Potencial Antioxidante de Bauhinia Kalbreyeri Harms (FABACEAE). Murillo, Elizabeth; Lombo, Oscar; Tique, Margarita; Méndez, Jonh J. // Información Tecnológica;2007, Vol. 18 Issue 6, p65 

    The article examines the antioxidant activity potential of Bauhinia Kalbreyeri Harms. The authors explain that the plant has been determined by the Colombian ethnomedicine as antidiabetic. They evaluate the extracts for free radicals by DPPH method. Ethanol mixed on the extracts showed the...

  • ANTIOXIDANTS. Mitchell, Terri // Life Extension;Aug2005, Vol. 11 Issue 8, p62 

    Discusses the origin of the antioxidant boom in the U.S. Conduct of research on Denham Harman's theory on free radicals and aging by physicist and chemist Duck Pearson and Sandy Shaw; Involvement of adventurer Jack Wheeler and television celebrity Merv Griffin in the promotion of antioxidants;...

  • ANTIOXIDANTS and cancer. Aberdour, Serenity // Alive;Apr2013, Issue 366, p65 

    The article offers information on antioxidants and how they can help in preventing or fighting cancer. It explains the so-called free radicals, which can lead to disease because they take electrons from other molecules that make them unstable. It claims that antioxidants can help fight disease...

  • 8. Dietary antioxidants: 8.3 Pro-oxidant activity of biological antioxidants.  // Vitamin & Mineral Requirements in Human Nutrition;2004, p145 

    Information on the pro-oxidant activity of biological antioxidants from Chapter 8 of the book "Vitamin and Mineral Requirements in Human Nutrition" is presented. Majority of biological antioxidants are antioxidants because when they accept an unpaired electron, the free radical intermediate...

  • Sports Nutrition.  // Total Health;Aug/Sep2007, Vol. 29 Issue 3, Special section p12 

    The article discusses the health benefits of taking the antioxidant Pycnogenol for sports nutrition. The superantioxidant properties make it ideal to fight dangerous effects of free radicals as a result of exercise which demands excess energy from the body. Research in General Physiology and...

  • Antioxidant and Free Radical Scavenging Properties of Twelve Traditionally Used Indian Medicinal Plants. Aqil, Farrukh; Ahmad, Iqbal; Mehmood, Zafar // Turkish Journal of Biology;2006, Vol. 30 Issue 3, p177 

    The methanolic crude extracts of 12 traditionally used Indian medicinal plants were screened for their antioxidant and free radical scavenging properties using α-tocopherol and butylated hydroxy toluene (BHT) as standard antioxidants. Antioxidant activity was measured by ferric thiocyanate...

  • Antioxidant (Levels). Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p46 

    The article presents an encyclopedia entry about antioxidants. Antioxidants are substances that can eliminate free radicals form the body, thus preventing them from damaging important cell components. Any reduction in the level of antioxidants will cause chronic activation of immune cells and...

  • Involvement of free radicals in animal diseases. Abd Ellah, Mahmoud Rushdi // Comparative Clinical Pathology;Dec2010, Vol. 19 Issue 6, p615 

    The balance between free radicals and antioxidants is disrupted in many diseases. This disruption may be attributed to a number of factors such as the inability of the cells to produce sufficient amounts of antioxidants, the nutritional deficiency of minerals or vitamins, and the excess...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics