Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype

January 2012
Molecular Cancer;2012, Vol. 11 Issue 1, p19
Academic Journal
The article presents a study that investigates the role of syndecan-2 protein in perineural invasion of pancreatic adenocarcinoma (PDAC) cells. The role of syndecan-two in invasion, migration and signaling of PDAC cells were analyzed through function in vitro assays and its expression was analyzed in human normal pancreas. It is found that SDC-2 silencing significantly reduced cell motility and invasiveness in the pancreatic cancer cell lines T3M4 and Su8686.


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