TITLE

Post-operative spondylodiscitis

AUTHOR(S)
Nasto, L. A.; Colangelo, D.; Rossi, B.; Fantoni, M.; Pola, E.
PUB. DATE
April 2012
SOURCE
European Review for Medical & Pharmacological Sciences;2012 Supplement, Vol. 16, p50
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Postoperative spine infections (PSIs) are a frequent and dreaded complication of spine surgery. Although different studies have been published, the prevalence of PSIs is thought to be about 5% for most spine surgical procedures. Different risk factors have been identified for PSIs. Among the others, extensive soft tissue dissection, longer operative time, soft tissue devitalization, and use of surgical instrumentation have been associated with higher risks of infection. Direct inoculation during surgery is the common infection route for PSIs. Gram-positive cocci (such as Staphylococcus aureus, Staphylococcus epidermidis and β-hemolytic streptococci) are the most common pathogens. Gram-negative bacteria also play a role in PSIs and may be associated with systemic illness and multisystem organ failure. A high level of suspicion is of paramount importance in early diagnosis of PSIs. Clinical symptoms of PSIs may be subtle and the infection may become apparent only in its late stages. Early diagnosis is the most important prognostic factor for PSIs. Although blood tests (i.e. ESR, CRP, and white blood cell count) and imaging studies (most commonly MRI) can be useful, it must be clear to the clinician that diagnostic modalities, either tissue biopsy or blood cultures, are of the utmost importance for diagnosing PSIs and devising a correct antibiotic therapy. Antibiotic therapy with early bracing (or bed rest) is the most commonly used treatment method for PSIs. Nevertheless, a more aggressive surgical treatment may be required in some patients. The goals of surgical treatment are to help the eradication of the infection, provide an adequate wound closure, and maintain spine column mechanical stability.
ACCESSION #
76318690

 

Related Articles

  • Late-onset neonatal infections: incidences and pathogens in the era of antenatal antibiotics. Didier, Capucine; Streicher, Marie-Pierre; Chognot, Didier; Campagni, Raphaèle; Schnebelen, Albert; Messer, Jean; Donato, Lionel; Langer, Bruno; Meyer, Nicolas; Astruc, Dominique; Kuhn, Pierre // European Journal of Pediatrics;Apr2012, Vol. 171 Issue 4, p681 

    Widespread use of intrapartum antimicrobial prophylaxis has significantly reduced the incidence of early-onset neonatal infection (EONI); however, little is known about the effects of increased maternal exposure to antibiotics on late-onset neonatal infection (LONI). This study aims to evaluate...

  • Application of the antibiotic batumin for accurate and rapid identification of staphylococcal small colony variants. Churkina, Larisa N; Bidnenko, Svetlana I; dos Santos Santiago, Guido Lopes; Vaneechoutte, Mario; Avdeeva, Lilja V; Lutko, Olga B; Oserjanskaja, Nadya M // BMC Research Notes;2012, Vol. 5 Issue 1, p374 

    Background: Staphylococcus aureus is a major human pathogen causing significant morbidity and mortality. The S. aureus colonies in osteomyelitis, in patients with cystic fibrosis and patients with endoprosthesis rejection frequently have an atypical morphology, i.e. staphylococcal small-colony...

  • The Constitutive Capacity of Human Keratinocytes to Kill Staphylococcus aureus Is Dependent on β-Defensin 3. Kisich, Kevin O.; Howell, Michael D.; Boguniewicz, Mark; Heizer, Heather R.; Watson, Nori U.; Leung, Donald Y. M. // Journal of Investigative Dermatology;Oct2007, Vol. 127 Issue 10, p2368 

    Normal skin is often exposed to bacteria, including potent pathogens such as E. coli, Staphylococcus aureus, and Streptococcus sp., but these microbes usually do not cause skin inflammation or infection in healthy individuals. Therefore, we hypothesized that there must be a constitutive...

  • Disinfection of football protective equipment using chlorine dioxide produced by the ICA TriNova system. Newsome, Anthony L.; DuBois, John D.; Tenney, Joel D. // BMC Public Health;2009, Vol. 9 Issue 1, p326 

    Background: Community-associated methicillin-resistant Staphylococcus aureus outbreaks have occurred in individuals engaged in athletic activities such as wrestling and football. Potential disease reduction interventions include the reduction or elimination of bacteria on common use items such...

  • Impact of the agr Quorum-Sensing System on Adherence to Polystyrene in Staphylococcus aureus. Cuong Vuong; Saenz, Henri L.; Gotz, Friedrich; Otto, Michael // Journal of Infectious Diseases;12/1/2000, Vol. 182 Issue 6 

    Biofilm formation by Staphylococcus aureus is a serious problem in nosocomial infections. There are great differences in the capacity of S. aureus to express biofilms, but the reasons are unknown. In all, 105 S. aureus strains were tested for a correlation between the agr quorum-sensing system...

  • Norway Stops Superbug.  // Current Science;4/16/2010, Vol. 95 Issue 15, p14 

    The article reports on the move of the Norwegian government to cut back on too much use of antibiotics for the treatment of Staphylococcus aureus infections (MRSA) among patients which have yielded into positive results and reduced the number of people infected by the bacteria.

  • Emergence, Mechanism, and Clinical Implications of Reduced Glycopeptide Susceptibility in Staphylococcus aureus. Geisel, R.; Schmitz, F.J.; Fluit, A.C.; Labischinski, H. // European Journal of Clinical Microbiology & Infectious Diseases;Oct2001, Vol. 20 Issue 10, p685 

    In order to understand the mechanism(s) of the resistance/reduced susceptibility of Staphylococcus aureus to glycopeptide antibiotics, the current data on the modes of action of glycopeptides were reviewed. In addition, the different test systems for detecting vancomycin resistance and the...

  • New antibiotic on the horizon? Barton, Samantha // Nature Reviews Microbiology;Aug2006, Vol. 4 Issue 8, p571 

    The article discusses the isolation and characterization of platensimycin. Platensimycin is a small molecule that corresponds to a new kind of antibiotic and has a wide, potent activity against Gram-positive pathogens. It also demonstrated how it terminated systemic Staphylococcus aureus...

  • What you should know about people, pets, MRSA, and bite wounds.  // Veterinary Medicine;Nov2011, Vol. 106 Issue 11, p550 

    The article focuses on the article published in the journal "Lancet Infection Diseases" which indicates the transmission patterns of methicillin-resistant Staphylococcus aureus (MRSA) between pets and humans. It notes the susceptibility of MRSA strains to antibiotics. The findings also showed...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics