TITLE

Effectiveness of 1 Dose of 2009 Influenza A (H1N1) Vaccine at Preventing Hospitalization With Pandemic H1N1 Influenza in Children Aged 7 Months–9 Years

AUTHOR(S)
Hadler, James L.; Baker, Tai N.; Papadouka, Vikki; France, Anne Marie; Zimmerman, Christopher; Livingston, Kara A.; Zucker, Jane R.
PUB. DATE
July 2012
SOURCE
Journal of Infectious Diseases;Jul2012, Vol. 206 Issue 1, p49
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The availability of a well-established immunization registry to provide vaccination information, a school-located vaccination campaign followed by continued 2009 influenza A (H1N1) (pH1N1) activity, and a requirement to report hospitalized influenza cases provided an opportunity to estimate vaccine effectiveness (VE) of an initial dose of pH1N1 monovalent vaccine in children aged 7 months–9 years. Seventy-eight case children and 729 date-of-birth– and zipcode-matched controls were studied. The VE of a single vaccine dose in preventing pH1N1 hospitalization ≥14 days after vaccination was 82% (95% confidence interval [CI], 0%–100%; P = .04) in children aged 3–9 years but was zero (−3%; 95% CI, <0%–75%) in children aged 7–35 months. These findings are consistent with those from prelicensure immunogenicity studies and have implications for interpretation of immunogenicity studies and setting priorities for vaccination of young children in future pandemics. Immunization registries can provide a simple, rapid assessment of VE to evaluate and inform vaccination policy.
ACCESSION #
76280842

 

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