TITLE

Experimental study of effects of compound resina draconis on protecting intestinal mucosa barrier in burned rats

AUTHOR(S)
Li Nan; Wang Xue-ming; Ji Yang; Zhu Jian-hua; Shi Yu-ling; Zhang Lin; Li Shu-lin; Zhai Jun-shan
PUB. DATE
August 2011
SOURCE
Journal of Chinese Clinical Medicine;Aug2011, Vol. 6 Issue 4, p20
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective To explore the protective effects of resina draconis on intestinal mucosa barrier in burned rats. Methods Seventy male Wistar rats (weighting 200 -250 g) were randomly divided into three groups: Group I (control group, n =10), Group II (n =30) ,Group III(n = 30). Group II and Group III were subjected to a 35% TBSA second degree scald in boiling water. Rats in Group III were gavaged with the compound resina draconis (20 mg/kg) at 0, 4 and 8 h post - burn. Rats in Group I and Group II received the same volume of saline injection. Ten animals were sacrificed in each burned group (Group II and Group III) at each time point (8, 12 and 24 h post - burn) and the rats in control group were sacrificed at 8 h post - burn. FITC - D in portal vein and IL - 1β, IL -4, IL -6, IL -10 in aorta ventralis were detected. Results The serum FITC - D, IL -1β and IL -6 levels post - burn were statistically significantly higher than that of the control group (P <0. 01), and significantly decreased after being gavaged with resina draconis (P <0. 01). The serum IL - 1β and IL - 6 levels of Group III were statistically lower than that of Group II and the opposite result of the serum IL -4 and IL - 10 levels was observed. Conclusion The increase of intestinal permeability and the serum IL - 1β and IL - 6 levels were observed in response to burn injuries. Resina draconis has the protective effects of inhibition of stress on intestinal mucosa barrier by inhibiting the generation of IL - 1β and IL -6, up - regulating anti - inflammatory cytokines such as IL -4 and IL - 10, correcting the abnormal immune function, lowering the function of immunocytes during inflammatory response, and thus is in favor of reducing inflammation and tissue healing and mitigating inflammation in the body and then protecting the function of major organs.
ACCESSION #
76117799

 

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