Experimental study of effects of compound resina draconis on protecting intestinal mucosa barrier in burned rats

Li Nan; Wang Xue-ming; Ji Yang; Zhu Jian-hua; Shi Yu-ling; Zhang Lin; Li Shu-lin; Zhai Jun-shan
August 2011
Journal of Chinese Clinical Medicine;Aug2011, Vol. 6 Issue 4, p20
Academic Journal
Objective To explore the protective effects of resina draconis on intestinal mucosa barrier in burned rats. Methods Seventy male Wistar rats (weighting 200 -250 g) were randomly divided into three groups: Group I (control group, n =10), Group II (n =30) ,Group III(n = 30). Group II and Group III were subjected to a 35% TBSA second degree scald in boiling water. Rats in Group III were gavaged with the compound resina draconis (20 mg/kg) at 0, 4 and 8 h post - burn. Rats in Group I and Group II received the same volume of saline injection. Ten animals were sacrificed in each burned group (Group II and Group III) at each time point (8, 12 and 24 h post - burn) and the rats in control group were sacrificed at 8 h post - burn. FITC - D in portal vein and IL - 1β, IL -4, IL -6, IL -10 in aorta ventralis were detected. Results The serum FITC - D, IL -1β and IL -6 levels post - burn were statistically significantly higher than that of the control group (P <0. 01), and significantly decreased after being gavaged with resina draconis (P <0. 01). The serum IL - 1β and IL - 6 levels of Group III were statistically lower than that of Group II and the opposite result of the serum IL -4 and IL - 10 levels was observed. Conclusion The increase of intestinal permeability and the serum IL - 1β and IL - 6 levels were observed in response to burn injuries. Resina draconis has the protective effects of inhibition of stress on intestinal mucosa barrier by inhibiting the generation of IL - 1β and IL -6, up - regulating anti - inflammatory cytokines such as IL -4 and IL - 10, correcting the abnormal immune function, lowering the function of immunocytes during inflammatory response, and thus is in favor of reducing inflammation and tissue healing and mitigating inflammation in the body and then protecting the function of major organs.


Related Articles

  • KaraciÄŸer ve böbrek üzerine etanolün toksisitesi ve L-NAME' in koruyucu etkisi. Kutlubay, Recep; Oğuz, Emin Oğuzhan; Turgut, Günfer; Kocamaz, Erdoğan // Medical Journal of Suleyman Demirel University;Dec2008, Vol. 15 Issue 4, p11 

    Aim: To show the histological liver and renal damage caused by ethanol at a certain dose and to show possible protective role of L-NAME. Materials and Methods: In this study, 40, 6 month-old Wistar rats were randomly divided into four groups: I- Control (n=10) II- Etanol (n=10) III-L-NAME (n=10)...

  • A bioabsorbable membrane (Seprafilm®) may prevent postoperative mediastinal adhesions following mediastinoscopy: an experimental study in rats. Büyükkale, Songül; Çıtak, Necati; İşgörücü, Özgür; Sayar, Adnan // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 7, p11544 

    Introduction: The aim of this experimental study was to investigate the anti-adhesion property of a bioabsorbable membrane following mediastinoscopy in a rat model. Methods: The study was conducted in 20 male Sprague-Dawley rats. Mediastinoscopy was performed all of them. Rats were divided into...

  • EFFECTS OF NIGELLA SATIVA AND SUNFLOWER OIL DIET ON WEIGHT OF ALBINO RATS. Buriro, Muhammad Anwar; Tayyab, Muhammad; Dttta, Allah // Professional Medical Journal;Oct2011, Vol. 18 Issue 3, p530 

    Objective: To study the effects of nigella sativa and sunflower oil on weight of albino rats. Study Design: Experimental study. Period: 1996 to 1997. Setting: PGMI, Lahore. Material & Methods: A study was conducted to determine the effects of nigella sativa and sunflower oil diet intake on body...

  • Effects of 8 Weeks of Endurance Training on the Concentration of 6-IL, Insulin in Male Rats. Yazdani, Behrooz; Dadkhah, Rezvan; Firozeh, Mahtab; Boni, Hossein Fallah Azad; Mohammadi, Mahbobeh // Advances in Environmental Biology;Apr2013, Vol. 7 Issue 4, p544 

    Skeletal muscle has the expression capacity of several cytokines, including IL-6, 8 and 15, together are called Myokine. In 2008, Handschin and Spiegelman have recognised the Myokines as the cytokines produced by the muscle cells that show the relationship between sport and inflammation...

  • Effect of resveratrol on inflammatory reaction after spinal cord injury in rats. LIU Chang-jiang; BI Wen-chao; ZHANG Chen; SHI Zhi-bin; WANG Kun-zheng // Journal of Xi'an Jiaotong University (Medical Sciences);Nov2013, Vol. 34 Issue 6, p779 

    Objective To study the effect of resveratrol on inflammatory reaction after spinal cord injury in Rats. Methods A total of 63 rats were randomly assigned into three groups with 21 in each: sham group, control group and resveratrol group. Rats in sham group underwent operation exposure only; the...

  • Influence of diltiazem in combination with a sucrose-rich diet on gingival alterations in rats. Corrêa, Fernanda Oliveira Bello; Faria, Lucas Moura; Fernandes-Filho, Romeu Belon; Spolidorio, Luís Carlos; Orrico, Silvana Regina Perez // Brazilian Oral Research;Jan-Mar2009, Vol. 23 Issue 1, p61 

    The aim of this study was to evaluate the influence of diltiazem in combination with a sucrose-rich diet on gingival alterations in rats. One hundred and twenty male Holtzman rats were randomly assigned to 10 groups (n = 12), being 2 control groups treated with saline and 8 test groups treated...

  • Effects of Afala and Antiestrogen ICI 182,780 in the Model of Hormone-Dependent Prostate Inflammation. Bernoulli, J.; Konkol, Y.; Vuorikoski, H.; Yatkin, E. // Bulletin of Experimental Biology & Medicine;Apr2014, Vol. 156 Issue 6, p807 

    In the hormone-dependent prostate inflammation model induced by implantation of slowreleasing pellets (50 mg testosterone and 5 mg estradiol) to Noble male rats, intragastric administration of Afala at a dose of 7.5 ml/kg for 18 weeks reduced the number of inflamed prostatic acini. The effect of...

  • Anti-aging Effects of Co-enzyme Q10 on Periodontal Tissues. Yoneda, T.; Tomofuji, T.; Ekuni, D.; Azuma, T.; Endo, Y.; Kasuyama, K.; Machida, T.; Morita, M. // Journal of Dental Research;Aug2013, Vol. 92 Issue 8, p735 

    Oxidative stress is associated with age-related reactions. The anti-oxidative effects of a reduced form of co-enzyme Q10 (rCoQ10) suppress oxidative stress, which may contribute to the prevention of age-related inflammatory reactions. We examined the effects of topically applied rCoQ10 on...

  • Tissue response to direct pulp capping with calcium hydroxide preceded by corticosteroid or corticosteroid/antibiotic dressing: a histological study in rats. Oliveira, Márcia de Freitas; Aparecida Giro, Elisa Maria; de Oliveira Ramalho, Lizeti Toledo; Abbud, Rosalin // Revista Odonto Ciencia;2009, Vol. 24 Issue 4, p377 

    Purpose: This study histologically evaluated the reaction of tooth pulp to treatment with calcium hydroxide in distilled water preceded by a corticosteroid (Decadron) or corticosteroid/antibiotic (Otosporin) dressing. Methods: Calcium hydroxide solution was applied to exposed tooth pulp for 5...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics