TITLE

Automatic determination of brain perfusion index for measurement of cerebral blood flow using spectral analysis and [sup 99m] Tc-HMPAO

AUTHOR(S)
Takasawa, Masashi; Murase, Kenya; Oku, Naohiko; Kawamata, Minoru; Imaizumi, Masao; Yoshikawa, Takuya; Osaki, Yasuhiro; Paul, Asit K.; Kitagawa, Kazuo; Matsumoto, Masayasu; Hori, Masatsugu
PUB. DATE
November 2002
SOURCE
European Journal of Nuclear Medicine & Molecular Imaging;2002, Vol. 29 Issue 11, p1443
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cerebral blood flow (CBF) can be non-invasively quantified using the brain perfusion index (BPI), determined from radionuclide angiographic data generated by technetium-99m hexamethylpropylene amine oxime ([sup 99m] Tc-HMPAO). We previously reported the use of a spectral analysis (SA) method using [sup 99m] Tc-HMPAO to calculate the BPI. In this report, we demonstrate an automatic method for determining the optimal BPI value and compare the optimal BPI values with the absolute CBF values measured using H[sub 2] [sup 15] O positron emission tomography (PET). Bilateral cerebral hemispheres of 11 patients with various brain diseases were examined using [sup 99m] Tc-HMPAO. In the automatic SA procedure, the radioactivity curve for the aortic arch (C[sub a] ) was shifted by 0–10 s. The radioactivity curve for the brain (C[sub b] ) was estimated using the shifted C[sub a] , and the error value between the actually measured and the estimated C[sub b] (Err) was calculated. When the Err was at a minimum, the BPI value was defined as optimal BPI. The difference in BPI from the optimal BPI was calculated as |BPI – optimal BPI| / optimal BPI×100 (%). In all participants, an H[sub 2] [sup 15] O PET examination was also performed, and the BPI values were compared with the absolute CBF values measured using H[sub 2] [sup 15] O PET (mCBF[sup PET] ). The difference between BPI and the optimal BPI increased significantly from 4.87%±1.69% to 18.38%±3.93% (mean±SD) when the Err value increased. The optimal BPI value (y) was well correlated with the mCBF[sup PET] value (x) (y=0.21x–0.0075, r=0.800). Our results suggest that this automatic SA method provides an accurate estimate of BPI that can be used for the quantification of CBF using [sup 99m] Tc-HMPAO SA.
ACCESSION #
7611196

 

Related Articles

  • Cingulate abnormalities associated with PANSS negative scores in first episode schizophrenia. Liz Ashton; Anna Barnes; Martin Livingston; David Wyper; The Scottish Schizophrenia Research Group // Behavioural Neurology;2000, Vol. 12 Issue 1/2, p93 

    There is evidence for the involvement of the cingulate gyrus in schizophrenia. We present details of a Statistical Parametric Mapping (SPM) analysis of SPECT data from the largest study (N = 39) of drug naive schizophrenic patients. The main findings are that there is decreased perfusion in the...

  • Intermittent antegrade/selective cerebral perfusion during circulatory arrest for repair of the aortic arch. Maas, C.; Kok, R.; Boogaart, A.; EIlander, S.; de Vries, I.; Ennema, J.; van der Starre, P.; Leicher, F.; Haalebos, M. // Perfusion;1997, Vol. 12 Issue 2, p127 

    If the aortic arch requires repair or replacement due to an aneurysm or dissection, conventional cardiopulmonary bypass (CPB) is not possible during the period in which the aortic arch is excluded from the circulation. This creates a situation in which there is no cerebral circulation. The brain...

  • Simplified quantitative determination of cerebral perfusion reserve with H[sub 2] [sup 15] O PET and acetazolamide. Arigoni, Michele; Kneifel, Stefan; Fandino, Javier; Khan, Nadia; Burger, Cyrill; Buck, Alfred // European Journal of Nuclear Medicine;2000, Vol. 27 Issue 10, p1557 

    Abstract. The measurement of regional cerebral bloodflow (rCBF) and perfusion reserve (PR) with H[sub 2][sup 15]O positron emission tomography (PET) and acetazolamide challenge is of importance in evaluating patients with cerebrovascular disease and is thought to be useful inselecting patients...

  • Regional cerebral blood flow single-photon emission tomography with [sup 99m] Tc-HMPAO and the acetazolamide test in the evaluation of vascular and Alzheimer's dementia. Pávics, László; Grünwald, Frank; Reichmann, Karl; Horn, Rolf; Kitschenberg, Anna; Hartmann, Alexander; Menzel, Christian; Schomburg, Axel G.; Overbeck, Bettina; Csernay, László; Biersack, Hans J. // European Journal of Nuclear Medicine;1999, Vol. 26 Issue 3, p239 

    Abstract. The diagnostic potential of technetium-99m hexamethylpropylene amine oxime (HMPAO) following systemic administration of the cerebral vasodilator acetazolamide (acetazolamide test) was evaluated by regional cerebral blood flow (rCBF) single-photon emission tomography (SPET) in patients...

  • Comparative evaluation of cerebral blood volume and cerebral blood flow in acute ischemic stroke by using perfusion-weighted MR imaging and SPECT. Kim, J.H.; Lee, E.-J.; Lee, S.-J.; Choi, N.-C.; Lim, B.H.; Shin, T. // Acta Radiologica;Jul2002, Vol. 43 Issue 4, p365 

    Purpose: To investigate the relationship between relative cerebral blood volume (CBV) measured with perfusion-weighted (PW) MR imaging and relative cerebral blood flow (CBF) measured with SPECT in acute ischemic stroke.Material and Methods: Fifteen patients who had...

  • Radiological progression of cerebral metastases after radiosurgery: assessment of perfusion MRI for differentiating between necrosis and recurrence. Hoefnagels, Friso W. A.; Lagerwaard, Frank J.; Sanchez, Esther; Haasbeek, Cornelis J. A.; Knol, Dirk L.; Slotman, Ben J.; Vandertop, W. Peter // Journal of Neurology;Jun2009, Vol. 256 Issue 6, p878 

    To assess the capability of perfusion MRI to differentiate between necrosis and tumor recurrence in patients showing radiological progression of cerebral metastases treated with stereotactic radiosurgery (SRS). From 2004 to 2006 dynamic susceptibility-weighted contrast-enhanced perfusion MRI...

  • Age-dependent effects of gradual decreases in cerebral perfusion pressure on the neurochemical response in swine. Walter, Bernd; Aisenpreis, Kristina; Fritz, Harald G.; Soukup, Jens; Eiselt, Michael; Bauer, Reinhard // Intensive Care Medicine;Jun2010, Vol. 36 Issue 6, p1067 

    There is still a lack of knowledge on the age-dependent relation between a reduction in cerebral perfusion pressure (CPP) and compromised brain perfusion leading to excessive transmitter release and brain damage cascades. The hypothesis is that an age-dependent lower threshold of cerebral blood...

  • Hemodynamic effects of decompressive craniotomy in MCA infarction: evaluation with perfusion CT. Bendszus, Martin; Müllges, Wolfgang; Goldbrunner, Roland; Weigand, Alexandra; Solymosi, Laszlo; Müllges, Wolfgang // European Radiology;Aug2003, Vol. 13 Issue 8, p1895 

    Decompressive craniotomy in hemispheric infarction has been reported to reduce mortality and improve outcome. Identifying tissue at risk and monitoring the benefit of craniotomy is hardly practical and has not been reported thus far. Perfusion CT was applied before and immediately after...

  • Direct measurement of nitrous oxide kinetics†. Drummond, G. B.; Fisher, L.; Pumphrey, O.; Kennedy, R. R. // BJA: The British Journal of Anaesthesia;Nov2012, Vol. 109 Issue 5, p776 

    Background Using conscious subjects, measurement of the effects of low concentrations of anaesthetic agents can allow the dynamics of onset and offset of the agent to be measured and kinetic values estimated. However, the tests have to be rapid and preferably assess cerebral function. Methods We...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics