TITLE

Targeting cathepsins: a new glimmer of hope for pancreatic cancer therapy?

AUTHOR(S)
Michl, Patrick
PUB. DATE
June 2012
SOURCE
Gut;Jun2012, Vol. 61 Issue 6, p790
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article provides information related to inhibition of cathepsin in cancer therapy. It is mentioned that cathepsin B expressed in pancreatic cancer cells and acts in both intracellular and extra cellular environment. Cathepsin B degrades collagens and enhances tumor cell migration. It is discussed that inhibition of cathepsin in tumor cells in the improvement of prognosis of pancreatic cancer.
ACCESSION #
76111425

 

Related Articles

  • Diabetes mellitus y su asociación con cáncer de páncreas en el anciano: reporte de caso y revisión de la bibliografía. Cuellar, René Bourlon; Balbuena, Micaela Martínez; Vera, Wisthon Moreira; de Pablo, Pamela Salcido; Gutiérrez, Pamela Vázquez // Medicina Interna de Mexico;sep/oct2010, Vol. 26 Issue 5, p512 

    No abstract available.

  • Menin, Histone H3 Methyltransferases, and Regulation of Cell Proliferation: Current Knowledge and Perspective. Xinjiang Wu; Xianxin Hua // Current Molecular Medicine;Dec2008, Vol. 8 Issue 8, p805 

    Menin is a tumor suppressor encoded by the MEN1 gene that is mutated in patients with an inherited syndrome, multiple endocrine neoplasia type 1 (MEN1). Loss of menin has potent impact on proliferation of endocrine and non-endocrine cells. However, until recently little has been known as to how...

  • Primary mediastinal large B-cell lymphoma (PMLBCL): long-term results from a retrospective multicentre Italian experience in 138 patients treated with CHOP or MACOP-B/VACOP-B. Todeschini, G.; Secchi, S.; Morra, E.; Vitolo, U.; Orlandi, E.; Pasini, F.; Gallo, E.; Ambrosetti, A.; Tecchio, C.; Tarella, C.; Gabbas, A.; Gallamini, A.; Gargantini, L.; Pizzuti, M.; Fioritoni, G.; Gottin, L.; Rossi, G.; Lazzarino, M.; Menestrina, F. // British Journal of Cancer;1/26/2004, Vol. 90 Issue 2, p372 

    The optimal treatment of primary mediastinal large B-cell lymphoma (PMLBCL) is still undefined. In the absence of randomised studies, we retrospectively analysed: (a) the effectiveness of two chemotherapy regimens (CHOP vs MACOP-B/VACOP-B) in complete remission (CR) achievement and event-free...

  • ASCO 2011.  // BioWorld Today;6/8/2011, Vol. 22 Issue 110, p4 

    The article reports on the Phase II small-cell lung cancer trial conducted by Cephalon Inc. which found that Bcl-2 inhibitor obatoclax plus chemotherapy showed a 64.9 percent response rate.

  • insulinoma (IN-suh-lih-NOH-mah).  // Diabetes Dictionary (NIDDK);10/1/2005, p21 

    A definition of the medical term "insulinoma" is presented. Insulinoma is a tumor of the beta cells in the pancreas. This condition may cause the body to make extra insulin, leading to hypoglycemia. The definition is from the "Diabetes Dictionary."

  • Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans. Meier, J. J.; Butler, A. E.; Galasso, R.; Rizza, R. A.; Butler, P. C. // Diabetologia;Nov2006, Vol. 49 Issue 11, p2689 

    Type 1 and type 2 diabetes are characterised by a beta cell deficit. Islet hyperplasia has been described in patients with Zollinger–Ellison syndrome secondary to gastrin-producing tumours (gastrinomas), and gastrin therapy has increased beta cell mass in rodents and human islets in...

  • Metabolic Effects of Eucaloric Lower-Carbohydrate Diet. Gower, Barbara A. // Fertility Weekly;4/21/2014, p6 

    The article reports on the findings of the study which shows that moderately reduced dietary carbohydrate (CHO) in a weight-maintaining diet helps the metabolic profile in women with polycystic ovary syndrome and may result in lower circulating levels of testosterone. The aim of the study which...

  • Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor-Induced Apoptosis of Pancreatic β-Cells. McKenzie, Mark D.; Carrington, Emma M.; Kaufmann, Thomas; Strasser, Andreas; Huang, David C. S.; Kay, Thomas W. H.; Allison, Janette; Thomas, Helen E. // Diabetes;May2008, Vol. 57 Issue 5, p1284 

    OBJECTIVE--Apoptosis of pancreatic β-cells is critical in both diabetes development and failure of islet transplantation. The role in these processes of pro- and antiapoptotic Bcl-2 family proteins, which regulate apoptosis by controlling mitochondrial integrity, remains poorly understood. We...

  • Regulated Exocytosis and Kiss-and-Run of Synaptic-Like Microvesicles in INS-1 and Primary Rat β-Cells. MacDonald, Patrick E.; Obermüller, Stefanie; Vikman, Jenny; Galvanovskis, Juris; Rorsman, Patrik; Eliasson, Lena // Diabetes;Mar2005, Vol. 54 Issue 3, p736 

    We have applied cell-attached capacitance measurements to investigate whether synaptic-like microvesicles (SLMVs) undergo regulated exocytosis in insulinoma and primary pancreatic β-cells. SLMV and large dense-core vesicle (LDCV) exocytosis was increased 1.6- and 2.4-fold upon stimulation...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics