TITLE

Synthesis of some NH-Derivatives of ciprofloxacin as antibacterial and antifungal agents

AUTHOR(S)
Rabbani, Mohammad Golam; Islam, Md. Rabiul; Ahmad, Mesbahuddin; Hossion, Abugafar M. L.
PUB. DATE
June 2011
SOURCE
Bangladesh Journal of Pharmacology;Jun2011, Vol. 6 Issue 1, p8
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Five NH-derivatives of ciprofloxacin (2-6) have been prepared by acetylation/ benzoylation on ciprofloxacin (1) in order to carry out screening for antibacterial activities on some gram-positive and gram-negative bacteria. The antifungal activity of these compounds has also been made against Candida albicans. All of the derivatives have shown enhanced activities against gram-negatives bacteria than parent antibiotic, ciprofloxacin among which compounds 2 and 6 are the most potent agents. Regarding the antifungal activity all of the compounds have shown highest activity than ciprofloxacin. All the compounds have been characterized with spectral analysis.
ACCESSION #
76109855

 

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