Design synthesis and biological evaluation of 2-methylphenyl semicarbazone derivatives

Singhal, Manmohan; Paul, Arindam; Singh, Hemendra Pratap
June 2011
Bangladesh Journal of Pharmacology;Jun2011, Vol. 6 Issue 1, p1
Academic Journal
We have used pharmacaphore hybridization technique of drug design and designed a pharmacophore model 2-methyphenysemicarbazone which is having hydrogent acceptor site, hydrogen donor site, lipophilic site etc using ligandscout-2.02 software. A series of 2-methylphenyl-semicarbazone was synthesized and evaluated for their antipyretic activity using boiled cow milk induced pyrexia in rabbits. Compound 11 was the most active compound. The possible metabolites of some selected synthesized chalconesemicarbazones were predicted by compratatEtmal method msinig Pallas version-3.1 ADME-Tox prediction software. The major pathway of metabolism was found to be p-hydrowylation and amide hydrolysis.


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