A Region of Chromosome 20 Is Linked to Leprosy Susceptibility in a South Indian Population

Tosh, Kerrie; Meisner, Sarah; Siddiqui, M. Ruby; Balakrishnan, Karuppiah; Ghei, Satish; Golding, Marina; Sengupta, Utpal; Pitchappan, Ramasamy M.; Hill, Adrian V.S.
October 2002
Journal of Infectious Diseases;10/15/2002, Vol. 186 Issue 8, p1190
Academic Journal
A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p 13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P = .00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P = .021), which suggests that a locus controlling susceptibility lies close to this marker.


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