TITLE

Effects of atmospheric pressure conditions on flow rate of an elastomeric infusion pump

AUTHOR(S)
WANG, JONG; MOELLER, ANNA; DING, YUANPANG SAMUEL
PUB. DATE
April 2012
SOURCE
American Journal of Health-System Pharmacy;4/1/2012, Vol. 69 Issue 7, p587
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose. The effects of pressure conditions, both hyperbaric and hypobaric, on the flow rate of an elastomeric infusion pump were investigated. Methods. The altered pressure conditions were tested with the restrictor outlet at two different conditions: (1) at the same pressure condition as the Infusor elastomeric balloon and (2) with the outlet exposed to ambient conditions. Five different pressure conditions were tested. These included ambient pressure (98-101 kilopascals [kPa]) and test pressures controlled to be 10 or 20 kPa below or 75 or 150 kPa above the ambient pressure. A theoretical calculation based on the principles of fluid mechanics was also used to predict the pump's flow rate at various ambient conditions. Results. The conditions in which the Infusor elastomeric pump and restrictor outlet were at the same pressure gave rise to average flow rates within the ±10% tolerance of the calculated target flow rate of 11 mL/hr. The flow rate of the Infusor pump decreased when the pressure conditions changed from hypobaric to ambient. The flow rate increased when the pressure conditions changed from hyperbaric to ambient. Conclusion. The flow rate of the Infusor elastomeric pump was not affected when the balloon reservoir and restrictor outlet were at the same pressure. The flow rate varied from 58.54% to 377.04% of the labeled flow rate when the pressure applied to the reservoir varied from 20 kPa below to 150 kPa above the pressure applied to the restrictor outlet, respectively. The maximum difference between observed flow rates and those calculated by applying fluid mechanics was 4.9%.
ACCESSION #
75505293

 

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