TITLE

Some General Considerations about the Clinicopathologic Aspects of Soft Tissue Tumors in Children and Adolescents

AUTHOR(S)
Coffin, Cheryl M.; Alaggio, Rita; Dehner, Louis P.
PUB. DATE
January 2012
SOURCE
Pediatric & Developmental Pathology;Jan/Feb2012 Supplement, p11
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Soft tissue tumors in children and adolescents are an important group of neoplasms, pseudoneoplasms, and tumefactive malformations with some distinctive clinicopathologic, genetic, syndromic, and therapeutic implications. In addition to the basic pathologic examination, there is the availability of diagnostic adjuncts in various settings based upon the histopathologic features that facilitate and/or corroborate a diagnosis. Immunohistochemistry, cytogenetics, molecular genetics, and an ever-increasing array of new technologies are available to address specific diagnostic questions and even potential therapeutic strategies. This review focuses upon some of the unique aspects of soft tissue tumors in children, including the classification, approach to the diagnosis, grading, clinical and pathologic staging, therapy-related changes, pathogenesis, and risk factors.
ACCESSION #
75386804

 

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