Mohideen, S.; Suresh Kumar, P.; Naneetha Krishnan, S.; Satyanarayana, T.; Shaji, G.; Surendranath, Y.; Saranya, P.
March 2012
International Journal of Pharmacy & Pharmaceutical Sciences;Mar2012, Vol. 4 Issue 2, p329
Academic Journal
The objective of the present investigation have developed a gastroretentive floating tablets for sustained release of venlafaxine hydrochloride by direct compression method. Various grades of low density polymers (HPMC K4M, HPMC K15M and Xanthan gum) were used for formulation of the tablets. The tablets were evaluated for thickness, weight variation, hardness, friability, drug content; in vitro buoyancy test, in vitro drug release and Fourier transform infrared (FT-IR) spectroscopy. Formulation F3 can be considered as an optimized formulation for gastroretentive floating tablet of venlafaxine HCl. The results of in vitro release studies showed that optimized formulation F3 could sustain drug release (98.05%) for 12 hours and remain buoyant for more than 12 hours. This formulation best fit model as matrix and it shows non-fickian type of drug release.


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