Review: Proton-pump inhibitors alleviate symptoms of functional (nonulcer) dyspepsia but may not be better than H[sub 2]-antagonists
- PPI Therapy Does Not Prevent Endoscopy in Dyspepsia. Ebell, Mark // American Family Physician;5/15/2003, Vol. 67 Issue 10, p2204
Discusses the study 'A Double Blind, Randomized, Placebo-Controlled Trial of Proton Pump Inhibitor therapy in Patients With Uninvestigated Dyspepsia,' by L. Rabeneck et al., from the December 2002 issue of the 'American Journal of Gastroenterology.'
- Review: Proton-pump inhibitor therapy reduces symptoms in nonulcer dyspepsia better than placebo: COMMENTARY. Veldhuyzen Van Zanten, Sander J. // ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p74
This article reports that the diagnosis of nonulcer dyspepsia (NUD) requires a normal endoscopy result, but this is poorly handled in a study, which reported that proton-pump inhibitor therapy reduces symptoms in nonulcer dyspepsia better than placebo. Before having endoscopy, many patients take...
- Functional dyspepsia: bye-bye to PPIs. Nyren, O. // Gut;Oct2002, Vol. 51 Issue 4, p464
Investigates the absence of therapeutic benefit of proton pump inhibitor therapy among Chinese patients with functional dyspepsia. Prevalence of dyspepsia; Production of symptoms in functional dyspepsia; Clinical manifestations; Implications for therapy.
- Esomeprazole 40 mg Once a Day in Patients with Functional Dyspepsia: The Randomized, Placebo-Controlled “ENTER” Trial. van Zanten, Sander Veldhuyzen; Armstrong, David; Chiba, Naoki; Flook, Nigel; White, Robert J.; Chakraborty, Bijan; Gasco, Ally // American Journal of Gastroenterology;Sep2006, Vol. 101 Issue 9, p2096
OBJECTIVE: The etiologies of functional dyspepsia (FD) are unclear, but in some studies, treatment with a proton pump inhibitor has been beneficial. The objective of this study was to evaluate the efficacy of esomeprazole 40 mg once a day compared to placebo in achieving symptom relief in...
- Lansoprazole ineffective for functional dyspepsia. Mounsey, Anne L. // Journal of Family Practice;Dec2002, Vol. 51 Issue 12, p1015
The article discusses research being done on the efficacy of different doses of lansoprazole, a proton pump inhibitor, on the treatment of functional dyspepsia. It references a study by W. M. Wong, B. C. Wong, W. K. Hung et al published in the 2002 issue of "Gut." The study found that...
- Dyspeptic Symptom Development After Discontinuation of a Proton Pump Inhibitor: A Double-Blind Placebo-Controlled Trial. Niklasson, Anna; Lindström, Lina; Simrén, Magnus; Lindberg, Greger; Björnsson, Einar // American Journal of Gastroenterology;Jul2010, Vol. 105 Issue 7, p1531
OBJECTIVES:Conflicting data exist on whether discontinuation of proton pump inhibitors (PPIs) is associated with rebound secretion of gastric acid.METHODS:A total of 48 healthy Helicobacter pylori-negative volunteers (24 females) were randomized in a double-blinded manner to treatment with...
- Review: Proton-pump inhibitor therapy reduces symptoms in nonulcer dyspepsia better than placebo. // ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p74
This article presents a study, which reports that proton-pump inhibitor (PPI) therapy reduces symptoms in nonulcer dyspepsia (NUD) better than placebo. The study method consisted of randomized controlled trials that compared PPI therapy with placebo, receptor antagonists, prokinetic therapy,...
- PPI can help mask tumours in dyspepsia. // Pulse;10/19/2011, Vol. 71 Issue 34, p14
The article offers tips on the use of proton pump inhibitor (PPI) in patient with dyspepsia.
- Omeprazole was effective in the short term for uninvestigated dyspepsia. Rabeneck, L.; Souchek, J.; Wristers, k.; Talley, Nicholas J. // ACP Journal Club;May/Jun2003, Vol. 138 Issue 3, p70
Summarizes a study that determined whether a proton-pump inhibitor is effective in the treatment of patients with uninvestigated dyspepsia. Characterization of the patients; Main outcome measures; Results of the study.