Synthesis of Some Quinolone Derivatives with Possible Local Anaesthetics Activities

Gupta, Ajay Kumar; Agarwal, A. K.; Mehra, S. C.
May 2012
Asian Journal of Chemistry;2012, Vol. 24 Issue 5, p2359
Academic Journal
Various new 7-[N-substituted acetyl amino]-2-methyl-4-quinolone were systheized by condensing 2-methyl-7-amino-4-quinolone with chloroacetyl chloride to get 2-methyl-7-chloroacetyl amino-4-quinolone, which on further reaction with various secondary amines to afford the required derivatives. The compounds were tested for their local anesthetic activity.


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