Repertoire of Gluten Peptides Active in Celiac Disease Patients: Perspectives For Translational Therapeutic Applications

Camarca, Alessandra; Del Mastro, Andrea; Gianfrani, Carmen
June 2012
Endocrine, Metabolic & Immune Disorders - Drug Targets;Jun2012, Vol. 12 Issue 2, p207
Academic Journal
Celiac disease is a common and lifelong food intolerance, affecting approximately 1% of the population. Because of a mechanism not completely understood, the ingestion of wheat gluten, and of homologue proteins of barley and rye, induces in genetically predisposed individuals pronounced inflammatory reactions mainly at the site of small intestine. Gluten, the triggering factor, is a complex protein mixture highly resistant to the gastrointestinal enzymatic proteolysis, and this results in the presence of large, and potentially immunogenic, peptides at the intestinal mucosa surface. During the last decade, several studies have defined gluten peptides able to stimulate adaptive T cells, of either CD4 or CD8 phenotype, and to activate innate (non T) immune cells. This review examines the complete repertoire of gluten peptides recognized by celiac T cells and discusses the several translational implications that the identification of these epitopes opens.


Related Articles

  • Toxic, Immunostimulatory and Antagonist Gluten Peptides in Celiac Disease. Silano, Marco; Vincentini, Olimpia; De Vicenzi, Massimo // Current Medicinal Chemistry;Apr2009, Vol. 16 Issue 12, p1489 

    Celiac disease (CD) is an increasingly diagnosed, permanent autoimmune enteropathy, triggered, in susceptible individuals, by the ingestion of gluten, the alcohol -- soluble protein fraction of some cereals, such as wheat, rye and barley. The main protein of wheat gluten is called gliadin, the...

  • Investigation of the putative immunodominant T cell epitopes in coeliac disease. Ellis, H.J.; Pollock, E.L.; Engel, W.; Fraser, J.S.; Rosen-Bronson, S.; Wieser, H.; Ciclitira, P.J. // Gut;Feb2003, Vol. 52 Issue 2, p212 

    Background: Coeliac disease (CD) is an enteropathy mediated by gluten specific T cells which secrete interferon γ (IFN-γ) when stimulated by gluten peptides presented by HLA-DQ2 or DQ8 molecules. Residues 62-75 of α[sub 2] gliadin have been proposed as the immunodominant epitope in the...

  • RÄ‚SPUNSUL IMUN IGE-MEDIAT ÃŽN BOALA CELIACÄ‚ LA COPIL. Samaşca, Gabriel; Dejica, Doru // Romanian Medical Journal;2010, Vol. 57 Issue 1, p66 

    Celiac disease appears when there is an inadequate immune response to gluten, a protein that finds itself in wheat. Adverse reactions to way may also be of allergic nature, because of the production of IgE antibodies against soluble proteins from wheat. The liaison between the two of them,...

  • T cells in peripheral blood after gluten challenge in coeliac disease. Anderson, R. P.; van Heel, D. A.; J A Tye-Din; Barnardo, M.; Salio, M.; Jewell, D. P.; Hill, A. V. S. // Gut;Sep2005, Vol. 54 Issue 9, p1217 

    Background: Current understanding of T cell epitopes in coeliac disease (CD) largely derives from intestinal T cell clones in vitro. I cell clones allow identification of gluten peptides that stimulate T cells but do not quantity their contribution to the overall gluten specific I cell response...

  • A novel and sensitive method for the detection of T cell stimulatory epitopes of &alph;/β- and γ-gliadin. Spaenij-Dekking, E. H. A.; Kooy-Winkelaar, E. M. C.; Nieuwenhuizen, W. F.; Drijfhout, J. W.; Koning, F. // Gut;Sep2004, Vol. 53 Issue 9, p1267 

    Background: It is now generally accepted that coeliac disease (CD) is caused by inflammatory T cell responses to gluten peptides bound to HLA-DQ2 or -DQ8 molecules. There is overwhelming evidence that CD patients can mount T cell responses to peptides found in both α-gliadin and γ-gliadin...

  • Endocytotic segregation of gliadin peptide 31–49 in enterocytes. Zimmer, Klaus-Peter; Fischer, Ina; Mothes, Thomas; Weissen-Plenz, Gabriele; Schmitz, Martina; Wieser, Herbert; Büning, Jürgen; Lerch, Markus M.; Ciclitira, Paul C.; Weber, Peter; Naim, Hassan Y. // Gut;Mar2010, Vol. 59 Issue 3, p300 

    Objective Coeliac disease (CD) is a multisystemic autoimmune inflammation of the intestinal tract induced by wheat gluten and related cereals in human leucocyte antigen (HLA)-DQ2/8-positive individuals. The molecular mechanisms relevant to oral tolerance induction towards toxic cereals such as...

  • Determination of B-Cell Epitopes in Patients with Celiac Disease: Peptide Microarrays. Choung, Rok Seon; Marietta, Eric V.; Van Dyke, Carol T.; Brantner, Tricia L.; Rajasekaran, John; Pasricha, Pankaj J.; Wang, Tianhao; Bei, Kang; Krishna, Karthik; Krishnamurthy, Hari K.; Snyder, Melissa R.; Jayaraman, Vasanth; Murray, Joseph A. // PLoS ONE;1/29/2016, Vol. 11 Issue 1, p1 

    Background: Most antibodies recognize conformational or discontinuous epitopes that have a specific 3-dimensional shape; however, determination of discontinuous B-cell epitopes is a major challenge in bioscience. Moreover, the current methods for identifying peptide epitopes often involve...

  • HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. Tollefsen, Stig; Arentz-Hansen, Helene; Fleckenstein, Burkhard; Molberg, Øyvind; Ráki, Melinda; Kwok, William W.; Jung, Günther; Lundin, Knut E. A.; Sollid, Ludvig M. // Journal of Clinical Investigation;Aug2006, Vol. 116 Issue 8, p2226 

    Celiac disease is associated with HLA-DQ2 and, to a lesser extent, HLA-DQ8. Type 1 diabetes is associated with the same DQ molecules in the opposite order and with possible involvement of trans-encoded DQ heterodimers. T cells that are reactive with gluten peptides deamidated by transglutaminase...

  • HLA-DQ8 as an Ir gene in coeliac disease. Lundin, K.E.A. // Gut;Jan2003, Vol. 52 Issue 1, p7 

    Reports on the immunogenicity of DQ8 restricted gliadin peptide in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs. Excellence of coeliac disease as a model for...


Read the Article


Sign out of this library

Other Topics