TITLE

Synthesis and Biological Activity of Heterocycles from Chalcone

AUTHOR(S)
Al-Ghulikah, H. A.
PUB. DATE
April 2012
SOURCE
Asian Journal of Chemistry;2012, Vol. 24 Issue 4, p1631
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The reaction between aromatic or heteroaromatic ortho-diamines and chalcone 1a,b is a convenient and versatile method for the preparation of condensed 1,4-diazepines 2a,b and 4a,b. 2,4-Diaryl-2,3-dihydro[1,5]benzothiazepines 5a,b were obtained from the condensation of chalcone 1a,b with 2-aminothiophenol in presence of catalytic amount of acid. The reaction of 2,3-diaminopyridine with chalcone dibromides 6a,b afforded the corresponding enaminoketones 7a,b, which cyclized to 6,8-diaryl-7,8-dihydro-9H-pyrido[4,5-b][1,4]diazepine 9a,b under acid condition. All synthesized compounds were characterized using IR,¹H NMR, 13C NMR, MS and elemental analysis. The compounds were screened for their antibacterial and antifungal activities. The synthesized compounds have shown activity against all the bacterial and fungal strains.
ACCESSION #
75068323

 

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