Protein interactions with piALU RNA indicates putative participation of retroRNA in the cell cycle, DNA repair and chromatin assembly

Blackwell, Benjamin J.; Lopez, Mary F.; Jianrong Wang; Krastins, Bryan; Sarracino, David; Tollervey, James R.; Dobke, Marek; Jordan, I. King; Lunyak, Victoria V.
January 2012
Mobile Genetic Elements (2159-2543);Jan/Feb2012, Vol. 2 Issue 1, p1
Academic Journal
Recent analyses suggest that transposable element-derived transcripts are processed to yield a variety of small RNA species that play critical functional roles in gene regulation and chromatin organization as well as genome stability and maintenance. Here we report a mass spectrometry analysis of an RNA-affinity complex isolation using a piRNA homologous sequence derived from Alu retrotransposal RNA. Our data point to potential roles for piALU RNAs in DNA repair, cell cycle and chromatin regulations.


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