Challenges in Interpretation of Thyroid Function Tests in PregnantWomen with Autoimmune Thyroid Disease

Feldt-Rasmussen, Ulla; Bliddal Mortensen, Anne-Sofie; Rasmussen, Ase Krogh; Boas, Malene; Hilsted, Linda; Main, Katharina
January 2011
Journal of Thyroid Research;2011, p1
Academic Journal
Physiological changes during gestation are important to be aware of in measurement and interpretation of thyroid function tests in women with autoimmune thyroid diseases. Thyroid autoimmune activity is decreasing in pregnancy. Measurement of serum TSH is the first-line screening variable for thyroid dysfunction also in pregnancy. However, using serum TSH for control of treatment of maternal thyroid autoimmunity infers a risk for compromised foetal development. Peripheral thyroid hormone values are highly different among laboratories, and there is a need for laboratory-specific gestational age-related reference ranges. Equally important, the intraindividual variability of the thyroid hormonemeasurements ismuch narrower than the interindividual variation (reflecting the reference interval). The best laboratory assessment of thyroid function is a free thyroid hormone estimate combined with TSH. Measurement of antithyroperoxidase and/or TSH receptor antibodies adds to the differential diagnosis of autoimmune and nonautoimmune thyroid diseases.


Related Articles

  • hypothyroidism.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1141 

    A definition of the term "hypothyroidism" is presented. It refers to inadequate levels of thyroid hormone in the body. Most individuals afflicted with the condition have either Hashimoto's thyroiditis or have undergone treatment of hyperthyroidism. It can be diagnosed with thyroid function...

  • Etiopathogenetic factors, thyroid functions and thyroid autoimmunity in melasma patients. Çakmak, Seray Külcü; Özcan, Nimet; Kılıç, Arzu; Koparal, Suha; Artüz, Ferda; Çakmak, Atıl; Köse, Kenan // Advances in Dermatology & Allergology / Postepy Dermatologii i A;Oct2015, Vol. 32 Issue 5, p327 

    Introduction: Melasma is a common chronic, acquired pigmentation disorder with a significant impact on the quality of life of patients. Aim: To investigate the etiopathogenetic factors, thyroid functions and thyroid autoimmunity in patients with melasma. Material and methods: Forty-five women...

  • Case report: When measured free T4 and free T3 may be misleading. Interference with free thyroid hormones measurements on Roche® and Siemens® platforms. Lewandowski, Krzysztof C.; Dąbrowska, Katarzyna; Lewiński, Andrzej // Thyroid Research;2012, Vol. 5 Issue 1, p11 

    A 59-year old female patient presented with apathy and 6 kg weight gain. Investigations revealed severe primary hypothyroidism (TSH>100 µIU/ml). L-thyroxine (L-T4) was started and titrated up to 75 µg, once daily, with clinical improvement. Other investigations revealed very high titres of...

  • Thyroid (dys-)function in normal and disturbed pregnancy. Budenhofer, Brigitte; Ditsch, Nina; Jeschke, Udo; Gärtner, Roland; Toth, Bettina // Archives of Gynecology & Obstetrics;Jan2013, Vol. 287 Issue 1, p1 

    Introduction: During pregnancy, physiologic changes in maternal thyroid function take place especially due to hormonal as well as metabolic processes. Human chorionic gonadotropin activates the maternal thyroid gland leading to increased thyroid hormone production. A sufficient availability of...

  • Smoking and Early Pregnancy Thyroid Hormone and Anti-Thyroid Antibody Levels in Euthyroid Mothers of the Northern Finland Birth Cohort 1986. Männistö, Tuija; Hartikainen, Anna-Liisa; Vääräsmäki, Marja; Bloigu, Aini; Surcel, Heljä-Marja; Pouta, Anneli; Järvelin, Marjo-Riitta; Ruokonen, Aimo; Suvanto, Eila // Thyroid;Sep2012, Vol. 22 Issue 9, p944 

    Background: Smokers in the general population have lower thyrotropin (TSH) and higher free triiodothyronine (fT3) and free thyroxine (fT4) concentrations, but the results in pregnant population vary from no effect to a decrease in TSH and fT4 concentrations and an increase in fT3 levels. Our...

  • The Optimal Treatment of Thyroid Gland Function Disturbances During Pregnancy. Drews, Krzysztof; Seremak-Mrozikiewicz, Agnieszka // Current Pharmaceutical Biotechnology;May2011, Vol. 12 Issue 5, p774 

    No abstract available.

  • Multiple Sclerosis and Hashimoto's Thyroiditis: A Case Report. ALTUNRENDE, Burcu; YILDIZ, Serpil; YILDIZ, Nebil; GÜREL, Kamil // Archives of Neuropsychiatry / Noropsikiatri Arsivi;Sep2011, Vol. 48 Issue 3, p224 

    It has been suggested that multiple sclerosis (MS) is an immune-mediated disease directed against central nervous system (CNS) myelin, although the exact pathogenesis is still unclear. There are a lot of reports regarding the coincidence of MS with other immune-mediated diseases. In recent...

  • Thyroid Hormones: Positive Relationships With Cognition in Healthy, Euthyroid Older Men. Prinz, Patricia N.; Scanlan, James M. // Journals of Gerontology Series A: Biological Sciences & Medical ;Mar99, Vol. 54 Issue 3, pM111 

    Examines thyroid-cognition relationships in healthy, euthyroid older men. Effect of aging on thyroid hormones; Use of multiple regressions; Criteria for subclinical hypothyroidism.

  • Euthyroid Sick Syndrome. Sharma, Sumit; Agrawal, Preeti; Kabadi, Udaya; Griffin, James E. // Primary Care Reports;Aug2008, Vol. 14 Issue 8, p81 

    The article explores the changes in thyroid hormone metabolism that are seen in patients with euthyroid sick syndrome and the current controversies in treatment of euthyroid sick syndrome with the administration of thyroid hormone. In about 70% of hospitalized patients with nonthyroidal illness...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics