Pathophysiology of chronic rhinosinusitis with nasal polyp

Hsu, Joy; Peters, Anju T.
September 2011
American Journal of Rhinology & Allergy;Sep/Oct2011, Vol. 25 Issue 5, p285
Academic Journal
Background: Chronic rhinosinusitis (CRS) is a common inflammatory condition of the paranasal sinuses and nasal passages. CRS with nasal polyp (CRSwNP) is a subtype of CRS, and the pathogenesis of CRSwNP remains largely unclear. Methods: This article reviews the literature regarding the pathophysiology of CRSwNP. Results: Evidence suggests that altered innate immunity, adaptive immunity, tissue remodeling, and/or effects of microorganisms may play a role in the development of CRSwNP. Aberrant arachidonic acid metabolism may also contribute to the pathogenesis of CRSwNP in patients with aspirin-exacerbated respiratory disease. Conclusion: There have been significant advances in the understanding pathophysiology of CRSwNP. Additional research is needed to elucidate these mechanisms and to determine their relative importance in the pathogenesis of CRSwNP.


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