TITLE

The Effect of Repetitive Transcranial Magnetic Stimulation on Gamma Oscillatory Activity in Schizophrenia

AUTHOR(S)
Barr, Mera S.; Farzan, Faranak; Arenovich, Tamara; Chen, Robert; Fitzgerald, Paul B.; Daskalakis, Zafiris J.
PUB. DATE
July 2011
SOURCE
PLoS ONE;2011, Vol. 6 Issue 7, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Gamma (c) oscillations (30-50 Hz) have been shown to be excessive in patients with schizophrenia (SCZ) during working memory (WM). WM is a cognitive process that involves the online maintenance and manipulation of information that is mediated largely by the dorsolateral prefrontal cortex (DLPFC). Repetitive transcranial magnetic stimulation (rTMS) represents a non-invasive method to stimulate the cortex that has been shown to enhance cognition and c oscillatory activity during WM. Methodology and Principal Findings: We examined the effect of 20 Hz rTMS over the DLPFC on c oscillatory activity elicited during the N-back task in 24 patients with SCZ compared to 22 healthy subjects. Prior to rTMS, patients with SCZ elicited excessive c oscillatory activity compared to healthy subjects across WM load. Active rTMS resulted in the reduction of frontal c oscillatory activity in patients with SCZ, while potentiating activity in healthy subjects in the 3-back, the most difficult condition. Further, these effects on c oscillatory activity were found to be specific to the frontal brain region and were absent in the parieto-occipital brain region. Conclusions and Significance: We suggest that this opposing effect of rTMS on c oscillatory activity in patients with SCZ versus healthy subjects may be related to homeostatic plasticity leading to differential effects of rTMS on c oscillatory activity depending on baseline differences. These findings provide important insights into the neurophysiological mechanisms underlying WM deficits in SCZ and demonstrated that rTMS can modulate c oscillatory activity that may be a possible avenue for cognitive potentiation in this disorder
ACCESSION #
74549070

 

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